Table 4

Paternal SSRI use before pregnancy and ASD in exposed and unexposed siblings from 5479 families

Paternal SSRI use before conceptionOffspring, nOffspring with ASD, nHR (95% CI)
CrudeModel 1*
No use during the last 3 months prior to conception279245RefRef
Use during the last 3 months prior to conception2687230.53 (0.31 to 0.91)0.74 (0.34 to 1.59)
  • *Adjusted for sex, parity, mother age, father age, maternal smoking, maternal AD use during pregnancy.

  • AD, antidepressant drug; ASD, autism spectrum disorder; n, number; SSRI, selective serotonin reuptake inhibitor.