Paternal SSRI use before pregnancy and ASD in exposed and unexposed siblings from 5479 families
| Paternal SSRI use before conception | Offspring, n | Offspring with ASD, n | HR (95% CI) | |
| Crude | Model 1* | |||
| No use during the last 3 months prior to conception | 2792 | 45 | Ref | Ref |
| Use during the last 3 months prior to conception | 2687 | 23 | 0.53 (0.31 to 0.91) | 0.74 (0.34 to 1.59) |
*Adjusted for sex, parity, mother age, father age, maternal smoking, maternal AD use during pregnancy.
AD, antidepressant drug; ASD, autism spectrum disorder; n, number; SSRI, selective serotonin reuptake inhibitor.