Table 3

Subgroup analyses for MACEs

Variable	Subgroup	Mild OSA (RR with 95% CI)	P value for mild OSA	Moderate OSA (RR with 95% CI)	P value for moderate OSA	Severe OSA (RR with 95% CI)	P value for severe OSA
Country	USA	1.00 (0.85 to 1.17)	0.977	1.14 (0.99 to 1.32)	0.064	1.90 (1.35 to 2.67)	<0.001
	Other	1.02 (0.19 to 5.52)	0.982	1.44 (0.83 to 2.50)	0.198	2.35 (1.52 to 3.65)	<0.001
	USA versus other	0.98 (0.18 to 5.32)*	0.982	0.79 (0.45 to 1.40)*	0.422	0.81 (0.46 to 1.41)*	0.453
Mean age	≥60	0.96 (0.86 to 1.08)	0.540	1.13 (0.97 to 1.33)	0.117	1.78 (1.23 to 2.57)	0.002
	<60	1.40 (0.73 to 2.70)	0.315	1.51 (0.94 to 2.41)	0.086	2.31 (1.64 to 3.24)	<0.001
	≥60 versus <60	0.69 (0.35 to 1.33)*	0.265	0.75 (0.46 to 1.23)*	0.252	0.77 (0.47 to 1.27)*	0.309
Gender	Male	0.92 (0.73 to 1.15)	0.455	1.10 (0.85 to 1.42)	0.449	1.81 (1.14 to 2.89)	0.012
	Female	1.97 (0.47 to 8.25)	0.353	1.36 (0.67 to 2.76)	0.399	1.98 (0.64 to 6.06)	0.234
	Male versus female	0.47 (0.11 to 1.99)*	0.304	0.81 (0.38 to 1.72)*	0.581	0.91 (0.27 to 3.08)*	0.885
BMI	≥30	1.75 (0.88 to 3.49)	0.111	1.70 (0.94 to 3.07)	0.079	2.72 (1.80 to 4.10)	<0.001
	<30	0.96 (0.86 to 1.07)	0.449	1.14 (0.99 to 1.31)	0.078	1.80 (1.36 to 2.38)	<0.001
	≥30 versus <30	1.82 (0.91 to 3.66)*	0.092	1.49 (0.81 to 2.74)*	0.198	1.51 (0.92 to 2.49)*	0.104
Disease statues	Healthy	1.00 (0.85 to 1.17)	0.977	1.16 (1.01 to 1.33)	0.034	2.12 (1.53 to 2.94)	<0.001
	Other	1.02 (0.19 to 5.52)	0.982	–	–	1.96 (1.01 to 3.81)	0.047
	Healthy versus Other	0.98 (0.18 to 5.32)*	0.982	–	–	1.08 (0.52 to 2.27)*	0.835
Follow-up duration	≥6	0.96 (0.86 to 1.07)	0.449	1.14 (0.99 to 1.31)	0.064	2.06 (1.43 to 2.95)	<0.001
	<6	1.75 (0.88 to 3.49)	0.111	1.74 (0.87 to 3.49)	0.120	2.10 (1.39 to 3.17)	<0.001
	≥6 versus <6	0.55 (0.27 to 1.10)*	0.092	0.66 (0.32 to 1.33)*	0.242	0.98 (0.57 to 1.70)*	0.945

*Reported as ratio of RR and 95% CI.
BMI, body mass index; MACES, major adverse cardiac events; OSA, obstructive sleep apnoea; RR, relative risk.