Table 2

Summary of methodological quality assessed with the QUADAS-222

First author’s name and year of publication	QUADAS-2: patient selection	QUADAS-2: index test	QUADAS-2: reference standard	QUADAS-2: flow and timing
First author’s name and year of publication	Could the selection of patients have introduced bias?	Could the conduct or interpretation of the index test have introduced bias?	Could the reference standard, its conduct, or its interpretation have introduced bias?	Could the patient flow have introduced bias?
Arora et al 21 2014	Yes	Yes	Yes	Yes
Arora et al 11 2015	Yes	Yes	No	Yes
Chadwick et al 12 2014	Yes	Yes	No	Yes
Kostikis et al 13 2015	Yes	Yes	No	Yes
Lagido et al 14 2014	Yes	Yes	Yes	Yes
Maier et al 15 2015	Yes	Yes	No	Yes
Ramlakhan et al 16 2011	Yes	Yes	Yes	Yes
Takuya et al 20 2015	Yes	Yes	Yes	Yes
Wadhawan et al 18 2011	Yes	Yes	No	Yes
Wadhawan et al 18 2011	Yes	Yes	Yes	Yes
Wolf et al 19 2013	Yes	Yes	Yes	Yes