Table 1

Descriptive characteristics of patients with incident atrial fibrillation in Denmark according to presence of mental health disorders before matching

Characteristics, % (n)No mental disorder
(n=252 238)
Schizophrenia
(n=534)
Severe depression
(n=400)
Bipolar disease
(n=569)
Demographic characteristics
 Female46.7 (117 876)45.7 (244)61.8 (247)59.6 (339)
 Mean age (SD)73.3 (13.1)64.5 (13.7)73.7 (14.0)73.0 (11.2)
Stroke risk factors and comorbidity
 Mean CHA2DS2-VASc score (SD)3.1 (1.8)2.5 (1.7)3.6 (2.0)3.3 (1.8)
 Mean HAS-BLED score (SD)2.2 (1.2)1.9 (1.3)2.5 (1.4)2.5 (1.3)
 Prior stroke16.9 (42 585)14.2 (76)30.3 (121)20.2 (115)
 Heart failure25.7 (64 704)30.0 (160)30.3 (121)29.3 (167)
 Hypertension42.6 (107 332)26.6 (142)44.5 (178)36.6 (208)
 Myocardial infarction10.3 (26 089)8.2 (44)11.3 (45)9.3 (53)
 Peripheral arterial disease7.6 (19 266)6.7 (36)10.0 (40)9.0 (51)
 Diabetes12.9 (32 606)24.3 (130)15.8 (63)20.2 (115)
 Prior bleeding26.4 (66 694)28.1 (150)44.0 (176)37.6 (214)
 Renal dysfunction5.2 (13 003)10.1 (54)8.5 (34)15.8 (90)
 Prior venous thromboembolism4.8 (12 081)7.3 (39)10.8 (43)10.0 (57)
 Chronic pulmonary disease14.5 (36 615)28.7 (153)22.3 (89)30.8 (175)
 Cancer15.9 (40 171)12.9 (69)14.8 (59)17.0 (97)
 Alcohol-related disease4.2 (10 471)19.1 (102)11.0 (44)20.9 (119)
Medication use within 365 days before index date
 Coumarin14.4 (36 326)5.1 (27)8.8 (35)12.1 (69)
 NOAC2.5 (6347)3.4 (18)2.3 (9)2.3 (13)
 Aspirin37.6 (94 951)33.0 (176)40.5 (162)38.1 (217)
 Clopidogrel4.3 (10 936)5.6 (30)9.0 (36)5.6 (32)
 NSAID26.7 (67 468)25.1 (134)27.3 (109)25.0 (142)
 Digoxin12.4 (31 200)9.9 (53)8.8 (35)12.1 (69)
 Non-loop diuretics36.2 (91 336)25.1 (134)38.8 (155)34.4 (196)
 Loop diuretics25.5 (64 337)34.8 (186)28.8 (115)36.0 (205)
 Beta-blocker32.2 (81 335)22.7 (121)28.0 (112)24.3 (138)
 Calcium channel blocker25.5 (64 355)17.0 (91)31.0 (124)25.1 (143)
 Renin-angiotensin inhibitor35.5 (89 621)23.8 (127)37.5 (150)32.0 (182)
 Statins24.6 (62 166)23.2 (124)26.0 (104)27.4 (156)
 Antiepileptics4.0 (10 077)24.3 (130)16.0 (64)39.5 (225)
 Anticholinergics0.2 (456)27.2 (145)2.3 (9)5.3 (30)
 Antipsychotics, lithium and anxiolytics/hypnotics27.1 (68 302)87.1 (465)63.2 (253)83.3 (474)
 Antidepressants14.5 (36 516)34.8 (186)78.5 (314)61.0 (347)
  • CHA2DS2-VASc; icongestive heart failure; hypertension; age ≥75 years; diabetes mellitus; prior stroke, transient ischemic attack or thromboembolism; vascular disease, age 65-74 years; female sex; HAS-BLED, hypertension; abnormal renal function; abnormal hepatic function; prior stroke; bleeding; labile INR (not available in this study); elderly age (aspirin, clopidogrel or non-steroidal anti-inflammatory drugs; alcohol intake; NOAC, non-vitamin K oral anticoagulant; NSAID, non-steroidal anti-inflammatory drugs.