Summary judgements on the appropriateness of 349 discordant strong recommendation based on low certainty in effect in UpToDate
| n(%) | |
| Appropriate discordant recommendations (consistent with GRADE) | |
| 1. Life-threatening (or catastrophical) situation | 70(20.1) |
| 2. Uncertain benefit, certain harm | 28(8.0) |
| 3. Potential similar benefits, one clearly less risky (or costly) | 56(16.0) |
| 4. Established similar benefits, one potentially more risky (or costly) | 18(5.2) |
| 5. Potential catastrophic harm | 32(9.2) |
| Total | 204(58.5) |
| Inappropriate discordant recommendations (inconsistent with GRADE) | |
| 6. Good practice statement | 47(13.5) |
| 7. Misclassification of certainty (judged moderate or high) | 38(10.9) |
| 8. Lack of explanation, should have been weak recommendation (GRADE 2C) | 60(17.2) |
| Total | 145(41.5) |
GRADE, Grading of Recommendations Assessment, Development and Evaluation.