Total (n=6836) | Breast conservative surgery (n=3876) | Mastectomy (n=2960) | |||||||
Diabetes (n=3418) | No diabetes (n=3418) | p Value | Diabetes (n=1938) | No diabetes (n=1938) | p Value | Diabetes (n=1480) | No diabetes (n=1480) | p Value | |
Age, mean (SD) | 70.14 (10.22) | 70.14 (10.22) | NA | 68.18 (9.53) | 68.18 (9.53) | NA | 72.71 (10.51) | 72.71 (10.51) | NA |
40–59 years, n (%) | 522 (15.27) | 522 (15.27) | NA | 343 (17.7) | 343 (17.7) | NA | 179 (12.09) | 179 (12.09) | NA |
60–79 years, n (%) | 2187 (63.98) | 2187 (63.98) | 1335 (68.89) | 1335 (68.89) | 852 (57.57) | 852 (57.57) | |||
≥80 years, n (%) | 709 (20.74) | 709 (20.74) | 260 (13.42) | 260 (13.42) | 449 (30.34) | 449 (30.34) | |||
Stage: local, n (%) | 2590 (75.78) | 2590 (75.78) | NA | 1560 (80.5) | 1560 (80.5) | NA | 1030 (69.59) | 1030 (69.59) | NA |
Stage: regional, n (%) | 799 (23.38) | 799 (23.38) | 371 (19.14) | 371 (19.14) | 428 (28.92) | 428 (28.92) | |||
Stage: distant, n (%) | 29 (0.85) | 29 (0.85) | 7 (0.36) | 7 (0.36) | 22 (1.49) | 22 (1.49) | |||
CCI0, n (%) | 2798 (81.86) | 3050 (89.23) | <0.001 | 1627 (83.95) | 1763 (90.97) | <0.001 | 1171 (79.12) | 1287 (86.96) | <0.001 |
CCI1, n (%) | 522 (15.27) | 324 (9.48) | 274 (14.14) | 155(8) | 248 (16.76) | 169 (11.42) | |||
CCI≥2, n (%) | 98 (2.87) | 44 (1.29) | 37 (1.91) | 20 (1.03) | 61 (4.12) | 24 (1.62) | |||
Vascular disease, n (%) | 301 (8.81) | 226 (6.61) | <0.001 | 159 (8.2) | 119 (6.14) | 0.011 | 142 (9.59) | 107 (7.23) | 0.019 |
Renal disease, n (%) | 141 (4.13) | 48 (1.40) | <0.001 | 61 (3.15) | 24 (1.24) | <0.001 | 80 (5.41) | 24 (1.62) | <0.001 |
Stroke/TIA/TEP, n (%) | 82 (2.40) | 55 (1.61) | 0.020 | 31 (1.60) | 22 (1.14) | 0.201 | 51 (3.45) | 33 (2.23) | 0.051 |
Congestive heart failure, n (%) | 66 (1.93) | 21 (0.61) | <0.001 | 21 (1.08) | 9 (0.46) | 0.020 | 45 (3.04) | 12 (0.81) | <0.001 |
Acute myocardial infarction, n (%) | 33 (0.97) | 18 (0.53) | 0.039 | 21 (1.08) | 7 (0.36) | 0.012 | 12 (0.81) | 11 (0.74) | 0.835 |
Obesity, n (%) | 450 (13.17) | 124 (3.63) | <0.001 | 267 (13.78) | 70 (3.61) | <0.001 | 183 (12.36) | 54 (3.65) | <0.001 |
Hypertension, n (%) | 2240 (65.54) | 1238 (36.22) | <0.001 | 1267 (65.38) | 654 (33.75) | <0.001 | 973 (65.74) | 584 (39.46) | <0.001 |
Smoking, n (%) | 166 (4.86) | 185 (5.41) | 0.288 | 111 (5.73) | 121 (6.24) | 0.488 | 55 (3.72) | 64 (4.32) | 0.393 |
Sentinel lymph node dissection, n (%) | 1697 (49.65) | 1795 (52.52) | 0.092 | 1184 (61.09) | 1257 (64.86) | 0.032 | 513 (34.66) | 538 (36.35) | 0.332 |
Axillary lymph node dissection, n (%) | 560 (16.38) | 551 (16.12) | 0.747 | 375 (19.35) | 382 (19.71) | 0.752 | 185 (12.5) | 169 (11.42) | 0.349 |
Infectious complications, n (%) | 95 (2.78) | 76 (2.22) | 0.138 | 35 (1.81) | 22 (1.14) | 0.088 | 60 (4.05) | 54 (3.65) | 0.560 |
Non-infectious complications, n(%) | 219 (6.40) | 156 (4.56) | 0.004 | 93 (4.80) | 53 (2.73) | 0.015 | 126 (8.51) | 103 (6.96) | 0.032 |
All complications (infectious and/or non-infectious), n (%) | 264 (7.72) | 181 (5.30) | 0.003 | 107 (5.57) | 59 (3.04) | 0.008 | 157 (10.60) | 122 (8.24) | 0.029 |
Length of stay, median (IQR) | 3 (2–5) | 3 (2–5) | 0.070 | 2 (1–3) | 2 (1–3) | 0.065 | 4 (3–6) | 4 (3–6) | 0.062 |
In-hospital mortality, n (%) | 5 (0.15) | 2 (0.06) | 0.277 | 2 (0.1) | 1 (0.05) | 0.571 | 3 (0.2) | 1 (0.07) | 0.341 |
p Value for difference between T2DM sufferers and matched controls using bivariate conditional logistic regression. Matching was conducted by age, province of residence, type of surgical procedure and stage.
CCI, Charlson Comorbidity Index; NA, not available; T2DM, type 2 diabetes mellitus.