Table 2

Standardised incidence ratios (SIRs) by age, sex and calendar period and 95% CIs of gastric cancer in all individuals exposed to proton pump inhibitors, stratified by sex and age groups

Gastric cancerGastric adenocarcinomaCardia cancerNon-cardia gastric cancer
Cases (n)SIR (95% CI)Cases (n)SIR (95% CI)Cases (n)SIR (95% CI)Cases (n)SIR (95% CI)
Total22193.38 (3.25 to 3.53)19433.38 (3.23 to 3.53)5673.55 (3.27 to 3.86)16523.33 (3.17 to 3.50)
Sex
 Men12963.65 (3.45 to 3.85)11663.66 (3.45 to 3.88)4373.84 (3.48 to 4.21)8593.56 (3.33 to 3.81)
 Women9233.07 (2.87 to 3.28)7773.02 (2.82 to 3.25)1302.84 (2.38 to 3.38)7933.11 (2.99 to 3.34)
Age, years
 <403622.76 (15.94 to 31.52)2725.30 (16.67 to 36.80)727.33 (10.95 to 56.30)2921.88 (14.65 to 31.43)
40–49947.36 (5.95 to 9.01)767.76 (6.11 to 9.71)247.54 (4.83 to 11.22)707.30 (5.69 to 9.23)
 50–593035.63 (5.01 to 6.30)2635.82 (5.14 to 6.57)945.50 (4.44 to 6.72)2095.69 (4.94 to 6.51)
 60–695763.85 (3.54 to 4.18)5013.81 (3.49 to 4.16)1913.94 (3.40 to 4.54)3853.81 (3.44 to 4.21)
≥7012102.76 (2.61 to 2.92)10762.77 (2.61 to 2.94)2512.77 (2.44 to 3.14)9592.76 (2.59 to 2.94)