Table 4

Standardised incidence ratios (SIRs) by age, sex and calendar period and 95% CIs of gastric cancer in all individuals exposed to proton pump inhibitors, stratified by indication

Gastric cancerCardia cancerNon-cardia gastric cancer
Cases (n)/totalSIR (95% CI)Cases (n)/totalSIR (95% CI)Cases (n)/totalSIR (95% CI)
All2219/797 0673.38 (3.25 to 3.53)567/797 0673.55 (3.27 to 3.86)1652/797 0673.33 (3.17 to 3.50)
Gastro-oesophageal reflux557/201 8683.04 (2.80 to 3.31)175/201 8683.84 (3.29 to 4.45)382/201 8682.78 (2.51 to 3.07)
Peptic ulcers721/79 5978.75 (8.12 to 9.41)71/79 5973.51 (2.74 to 4.43)650/79 59710.45 (9.66 to 11.28)
Gastroduodenitis350/104 9553.68 (3.31 to 4.09)63/104 9552.71 (2.09 to 3.47)287/104 9553.99 (3.55 to 4.48)
Dyspepsia136/43 9013.07 (2.58 to 3.63)33/43 9013.10 (2.13 to 4.35)103/43 9013.07 (2.50 to 3.72)
Helicobacter pylori440/58 3669.76 (8.87 to 10.71)48/58 3664.19 (3.09 to 5.55)392/58 36611.67 (10.53 to 12.87)
No H. pylori1779/781 9552.91 (2.78 to 3.05)519/781 9553.50 (3.21 to 3.82)1302/781 9552.73 (2.58 to 2.88)
NSAID exposure347/256 5981.82 (1.64 to 2.03)94/256 5982.07 (1.67 to 2.53)253/256 5981.75 (1.54 to 1.97)
Only NSAID exposure93/118 9871.41 (1.14 to 1.73)36/118 9872.29 (1.60 to 3.17)57/118 9871.14 (0.86 to 1.48)
Aspirin exposure872/293 5902.42 (2.26 to 2.60)211/293 5902.73 (2.37 to 3.13)588/293 5902.33 (2.14 to 2.53)
Only aspirin exposure252/126 8831.93 (1.70 to 2.18)85/126 8832.73 (2.18 to 3.37)169/126 8831.68 (1.43 to 1.95)
  •  One individual could have different indications, except for the group exposed only to NSAIDs or aspirin.

  • NSAIDs, non-steroidal anti-inflammatory drugs.