Time and events table
| Required measurements | Screening (before registration) | During treatment | 7days before operation | 8 weeks after operation |
| Informed consent | ◆ | |||
| Subjective/objective symptom, toxicity/compliance | ◆* | ◆ | ||
| Physical assessment (including weight, height) | ◆* | |||
| ECOG PS | ◆* | ◆ | ||
| Blood count | ◆* | ◆ | ||
| Bilirubin, AST, ALT, alkaline phosphatase, albumin, amylase, creatinine, sodium, potassium | ◆* | ◆ | ||
| Blood urea nitrogen, C reactive protein, fasting blood glucose | ◆* | ◆ | ||
| History | ◆* | |||
| Creatinine clearance | ◆* | |||
| 12-lead ECG | ◆† | ◆ | ||
| CEA, CA19-9 | ◆† | ◆§ | ◆ | |
| HBs-Ag, HCV-Ab | ◆‡ | |||
| Chest X-ray | ◆† | |||
| Upper gastrointestinal endoscopy | ◆† | |||
| MDCT with a pancreas CT protocol involving triphasic (ie, arterial, late arterial, and venous phases) cross-sectional imaging with thin slices | ◆‡ | ◆§ | ||
| Chest-abdominopelvic CT+contrast | ◆ | |||
| FDG-PET | ◆† | ◆§ |
◆ A single measurement is required on the corresponding day.
◇ Weekly mesurements are required in the corresponding period.
*A measurement should be taken ≦7 days before registration.
†A measurement should be taken ≦14 days before registration.
‡A measurement should be taken ≦28 days before registration.
§A measurem ent should be taken ≦28 days after end of chemoradiation.
ECOG: Eastern Cooperative Oncology Group; PS: performance status; AST: aspartate transaminase; ALT: alanine transaminase; CEA: carcinoembryonic antigen; HBs-Ag: hepatitis B surface antigen; HCV-Ab: hepatitis C virus antibody; FDG-PET: Fluorodeoxyglucose-position emission tomography; MDCT: multidetector CT.