Logistic regression analysis of cycles
| Variable | Clinical pregnancy OR (95% CI) | Live birth OR (95% CI) | |||||||
| Univariate analysis | p Value | Multivariate analysis | p Value | Univariate analysis | p Value | Multivariate analysis | p Value | ||
| Growth hormone group | (–)GH | 1.00 | – | 1.00 | – | 1.00 | – | 1.00 | – |
| (+)GH | 2.49 (1.42 to 4.37) | 0.002 | 3.42 (1.82 to 6.44) | 0.000 | 4.75 (2.30 to 9.79) | 0.000 | 6.16 (2.83 to 13.39) | 0.000 | |
| Age | 0.90 (0.86 to 0.95) | 0.000 | 0.87 (0.81 to 0.94) | 0.000 | 0.91 (0.86 to 0.96) | 0.000 | 0.89 (0.83 to 0.96) | 0.003 | |
| Serum AMH | 1.01 (0.99 to 1.04) | 0.372 | – | – | 1.00 (0.97 to 1.04) | 0.824 | – | – | |
| BMI | 1.03 (0.99 to 1.08) | 0.178 | – | – | 1.01 (0.96 to 1.07) | 0.662 | – | – | |
| Number of embryos transferred | 1.26 (0.81 to 1.94) | 0.303 | – | – | 1.25 (0.76 to 2.06) | 0.386 | – | – | |
| AFC groups | Group A (≥20 follicles) | 1.00 | – | 1.00 | – | 1.00 | – | 1.00 | – |
| Group B (13–19 follicles) | 0.67 (0.29 to 1.53) | 0.338 | 1.15 (0.37 to 3.58) | 0.816 | 0.93 (0.36 to 2.39) | 0.883 | 2.69 (0.65 to 11.15) | 0.174 | |
| Group C (9–12 follicles) | 0.93 (0.44 to 1.96) | 0.841 | 1.36 (0.46 to 4.03) | 0.584 | 0.92 (0.38 to 2.26) | 0.857 | 2.46 (0.59 to 10.16) | 0.215 | |
| Group D (5–8 follicles) | 0.71 (0.36 to 1.41) | 0.327 | 2.02 (0.73 to 5.58) | 0.177 | 0.84 (0.37 to 1.90) | 0.681 | 2.48 (0.63 to 9.80) | 0.195 | |
| Group E (≤4 follicles) | 0.32 (0.13 to 0.78) | 0.012 | 1.27 (0.36 to 4.47) | 0.709 | 0.35 (0.12 to 1.03) | 0.057 | 1.61 (0.2 to 8.08) | 0.562 | |
| Stimulation protocol | Antagonist cycle | 1.00 | – | – | – | 1.00 | – | – | – |
| Agonist cycle | 0.98 (0.60 to 1.60) | 0.936 | – | – | 0.95 (0.54 to 1.66) | 0.859 | – | – | |
| Other cycle (downregulation) | 0.95 (0.52 to 1.75) | 0.873 | – | – | 0.64 (0.30 to 1.40) | 0.266 | – | – | |
| Embryo development stage | Cleavage | 1.00 | – | – | – | 1.00 | – | – | – |
| Blastocyst | 3.25 (1.81 to 5.85) | 0.000 | – | – | 2.93 (1.51 to 5.68) | 0.001 | – | – | |
| Quality of transferred embryo | Low-quality day-3 | 1.00 | – | 1.00 | – | 1.00 | – | 1.00 | – |
| High-quality blastocyst | 5.00 (2.05 to 12.18) | 0.000 | 7.55 (2.29 to 24.90) | 0.001 | 3.90 (1.32 to 11.55) | 0.014 | 3.86 (0.88 to 16.93) | 0.073 | |
| Medium-quality blastocyst | 4.13 (1.57 to 10.83) | 0.004 | 3.94 (0.89 to 17.46) | 0.071 | 4.55 (1.52 to 13.67) | 0.007 | 1.68 (0.20 to 14.46) | 0.637 | |
| Low-quality blastocyst | 3.14 (0.81 to 12.25) | 0.099 | 0.75 (0.08 to 7.56) | 0.809 | 5.46 (1.36 to 21.95) | 0.017 | 1.00 (0.09 to 10.84) | 0.999 | |
| High-quality day-3 | 1.90 (1.15 to 3.13) | 0.120 | 2.24 (1.13 to 4.45) | 0.022 | 2.48 (1.36 to 4.52) | 0.003 | 2.01 (0.91 to 4.46) | 0.084 | |
| Number of infertility factors | None or one factor | 1.00 | – | – | – | 1.00 | – | – | – |
| Two factors | 0.66 (0.41 to 1.04) | 0.075 | – | – | 0.72 (0.42 to 1.23) | 0.228 | – | – | |
| Three or more factors | 0.61 (0.27 to 1.38) | 0.235 | – | – | 0.70 (0.28 to 1.76) | 0.445 | – | – | |
| Number of previous IVF attempts | No previous attempts | 1.00 | – | – | – | 1.00 | – | – | – |
| One previous attempts | 1.29 (0.77 to 2.18) | 0.334 | – | – | 1.01 (0.55 to 1.85) | 0.981 | – | – | |
| Two previous attempts | 1.46 (0.71 to 3.01) | 0.304 | – | – | 0.86 (0.34 to 2.19) | 0.757 | – | – | |
| Three or more previous attempts | 1.21 (0.62 to 2.38) | 0.583 | – | – | 1.32 (0.64 to 2.74) | 0.453 | – | – | |
The presence of GH, patient’s age, AFC rating, transferred embryo development stage and quality were the only significant variables that affected clinical pregnancy or live birth chance. When adjusting for these variable in a multivariate logistic analysis, the effect of each parameter became stronger, as reflected by increased ORs.
AFC, antral follicle count; AMH, anti-Mullerian hormone; BMI, body mass index; GH, growth hormone; IVF, in vitro fertilisation.