Table 3

Clinical or haemodynamic variables measured in substudies

NoVariable (units)AbbreviationMethod of measuringN
1Peripheral tissue oxygen saturation (%)StO2 Near-infrared spectroscopy29
2+10Vertical hyperechoic artefacts (‘rocket beams’) (n)B-linesCCUS556
3+9Change in cardiac output with PEEP increase (L/min)ΔCO-PEEPCCUS11
4Tricuspid annular peak systolic excursion (mm)TAPSECCUS391
4Right ventricle S’ of the tricuspid annulus (cm/s)RV S’CCUS373
5Common carotid artery flow (L/min)CCA flowCCUS59
5Subclavian artery flow (L/min)SCA flowCCUS59
5Common femoral artery flow (L/min)CFA flowCCUS59
5Abdominal flow (L/min)Calculation: Cardiac output − (CCA flow + SCA flow + CFA flow)59
6*Cardiac output calculated with FloTrac (L/min)APCOArterial pressure waveform analysis14
7*Repeated measurementsΔ-measures of basic study46
8Tricuspid insufficiency (cm/s)TICCUS39
8Right ventricle end systolic diameter (mm)RVESdCCUS78
9Delta heart rate (bpm)ΔHRBedside monitor3
9Delta-systolic, diastolic and mean arterial pressures (mm Hg)ΔSBP, ΔDBP, ΔMAPBedside monitor3
9Delta expiratory end-tidal carbon dioxide (cmH2O)ΔEtCO2 Mechanical ventilator3
10Presence or absence of ARDSChest radiography
11Myocardial strain (%)ƐCCUS
11Myocardial strain rate (1/s)Ɛ / SRCCUS
  • *Sub-studies 6 and 7 include only patients in a state of circulatory shock.

  • ARDS, acute respiratory distress syndrome; CCUS, critical care ultrasound; N,number; PEEP, positive end-expiratory pressure.