Table 1

Baseline characteristics of patients with stroke according to thiazide use after propensity score matching

Thiazide usep Value
Yes (n=3735)No (n=3735)
Demographic factors
Age (years)0.280
 <60862 (23.1%)811 (21.7%)
 60–792211 (59.2%)2274 (60.9%)
 ≥80662 (17.7%)650 (17.4%)
Sex0.374
 Male2171 (58.1%)2133 (57.1%)
 Female1564 (41.9%)1602 (42.9%)
Socioeconomic factors
Income level (NTD)0.267
 Financially dependent1110 (29.7%)1120 (30.0%)
 1–19 9991953 (52.3%)1910 (51.1%)
 20 000–39 999455 (12.2%)448 (12.0%)
 ≥40 000217 (5.8%)257 (6.9%)
Urbanisation level0.658
 1 (most urbanised)908 (24.3%)953 (25.5%)
 21024 (27.4%)988 (26.5%)
 3685 (18.3%)691 (18.5%)
 4636 (17.0%)610 (16.3%)
 5 (least urbanised)482 (12.9%)493 (13.2%)
Comorbidities
 Charlson Comorbidity Index2.84±1.832.83±1.860.822
 Hypertension3319 (88.9%)3331 (89.2%)0.657
 Diabetes mellitus1612 (43.2%)1598 (42.8%)0.744
 Congestive heart failure384 (10.3%)394 (10.5%)0.705
 COPD736 (19.7%)731 (19.6%)0.884
 Chronic liver disease347 (9.3%)332 (8.9%)0.546
 Chronic kidney disease351 (9.4%)364 (9.7%)0.609
 Malignancy197 (5.3%)206 (5.5%)0.645
 Osteoporosis218 (5.8%)214 (5.7%)0.843
 Rheumatoid arthritis40 (1.1%)34 (0.9%)0.483
 Parkinsonism126 (3.4%)128 (3.4%)0.898
 Dementia195 (5.2%)207 (5.5%)0.538
 Depression170 (4.6%)173 (4.6%)0.868
 Epilepsy51 (1.4%)43 (1.2%)0.406
Stroke severity proxies
 SSI score5.78±3.705.78±3.660.954
 ICU408 (10.9%)405 (10.8%)0.911
 Mechanical ventilation87 (2.3%)97 (2.6%)0.455
 Hemiplegia or paraplegia631 (16.9%)588 (15.7%)0.178
 Aphasia58 (1.6%)57 (1.5%)0.925
 Neurosurgery13 (0.3%)14 (0.4%)0.847
Use of medication
Antihypertensive drugs other than thiazides
 ACEI, ARB1543 (41.3%)1539 (41.2%)0.925
 Calcium channel blockers1720 (46.1%)1754 (47.0)0.430
 β-blockers1128 (30.2%)1158 (31.0)0.451
 Loop diuretics318 (8.5%)325 (8.7%)0.773
 Aldosterone receptor antagonists84 (2.2%)89 (2.4%)0.701
Anxiolytics, antipsychotics, sedatives or antidepressants1164 (31.2%)1184 (31.7%)0.618
Systemic corticosteroids225 (6.0%)238 (6.4%)0.533
Osteoporosis medication130 (3.5%)130 (3.5%)1.000
  • Continuous data expressed as mean±SD and categorical data expressed as number (%).

  • ACEI, ACE inhibitors; ARB, angiotensin receptor blocker; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; NTD, New Taiwan dollars; SSI, Stroke Severity Index.