Baseline characteristics of the patients
| Characteristics | Survivor (N=994) | Non-survivor (n=504) | p Value |
| Age (years) | 70 (58–78) | 73 (62–80) | 0.0001 |
| Sex (male/female) | 560/434 | 329/175 | 0.0009 |
| Baseline values | |||
| SIRS score | 3 (2–4) | 3 (2–4) | 0.0556 |
| SIRS score≧3 | 625 (62.9%) | 341 (67.7%) | 0.0677 |
| JAAM-DIC score | 5 (4–7) | 6 (5–7) | 0.0019 |
| Platelet count (×109L) | 61 (36–89) | 49 (29–78) | <0.0001 |
| FDP (μg/mL) | 25.3 (13.0–51.9) | 25.4 (12.2–51.7) | 0.7788 |
| PT ratio | 1.30 (1.16–1.48) | 1.36 (1.21–1.64) | <0.0001 |
| Organ dysfunction | |||
| Total SOFA | 5 (3–6) | 5 (4–7) | <0.0001 |
| Respiratory SOFA≧2* (PaO2/FiO2<300) | 621 (62.5%) | 395 (78.4%) | <0.0001 |
| Cardiovascular SOFA≧2* (requirement of vasopressors) | 636 (64.0%) | 349 (69.3%) | 0.0426 |
| Hepatic SOFA≧2* (bilirubin≧2.0 mg/dL)* | 272 (27.4%) | 202 (40.8%) | <0.0001 |
| Renal SOFA≧2* (creatinine≧2.0 mg/dL) | 326 (32.8%) | 221 (43.8%) | <0.0001 |
Total SOFA is the sum the four items (respiratory SOFA, cardiovascular SOFA, hepatic SOFA, renal SOFA). The score of total SOFA is defined as 2 if the total score exceeded 2.
*Defined according to the Third International Consensus for Sepsis and Septic Shock.13
DIC, disseminated intravascular coagulation; FDP, fibrinogen/fibrin degradation product; FiO2, fractional inspired oxygen; JAAM, Japanese Association for Acute Medicine; PaO2, partial pressure of oxygen; PT, prothrombin time; SIRS, systemic inflammatory response syndrome; SOFA, Sequential Organ Failure Assessment.