Table 1

Baseline characteristics of the patients

CharacteristicsSurvivor (N=994)Non-survivor (n=504)p Value
Age (years)70 (58–78)73 (62–80)0.0001
Sex (male/female)560/434329/1750.0009
Baseline values
 SIRS score3 (2–4)3 (2–4)0.0556
 SIRS score≧3625 (62.9%)341 (67.7%)0.0677
 JAAM-DIC score5 (4–7)6 (5–7)0.0019
 Platelet count (×109L) 61 (36–89)49 (29–78)<0.0001
 FDP (μg/mL)25.3 (13.0–51.9)25.4 (12.2–51.7)0.7788
 PT ratio1.30 (1.16–1.48)1.36 (1.21–1.64)<0.0001
Organ dysfunction
 Total SOFA5 (3–6)5 (4–7)<0.0001
  Respiratory SOFA≧2* (PaO2/FiO2<300)621 (62.5%)395 (78.4%)<0.0001
  Cardiovascular SOFA≧2* (requirement of vasopressors)636 (64.0%)349 (69.3%)0.0426
  Hepatic SOFA≧2* (bilirubin≧2.0 mg/dL)*272 (27.4%)202 (40.8%)<0.0001
  Renal SOFA≧2* (creatinine≧2.0 mg/dL)326 (32.8%)221 (43.8%)<0.0001
  • Total SOFA is the sum the four items (respiratory SOFA, cardiovascular SOFA, hepatic SOFA, renal SOFA). The score of total SOFA is defined as 2 if the total score exceeded 2.

  • *Defined according to the Third International Consensus for Sepsis and Septic Shock.13

  • DIC, disseminated intravascular coagulation; FDP, fibrinogen/fibrin degradation product; FiO2, fractional inspired oxygen; JAAM, Japanese Association for Acute Medicine; PaO2, partial pressure of oxygen; PT, prothrombin time; SIRS, systemic inflammatory response syndrome; SOFA, Sequential Organ Failure Assessment.