Table 3
Interim analyses stopping rules
Analysis
Two-sided p Value
Probability of stopping
(80% power) (%)
Probability of stopping
(90% power) (%)
First (350 patients)
<0.0007
4.9
8.5
Second (620 patients)
<0.014
40.2
51.2
Final
<0.046
34.9
30.4