Table 1

Top 10 ranked research questions for miscarriage

PriorityResearch question
1What are the effective interventions to prevent miscarriage, threatened miscarriage and recurrent miscarriage? (eg, lifestyle, vitamins, aspirin, early scans, human chorionic gonadotrophin(HCG), dopamine agonists, progestogen, polytherapy, steroids, oestrogen, metformin, anticoagulants, intravenous immunoglobulin, intralipid and anti-TNF-alpha)
2What are the emotional and mental health impacts of miscarriage in the short term and long term for the mother and the partner?
3What investigations are of true clinical value? (eg, ultrasound, gene sequencing, natural killer cells, thromboelastography, microarray testing of the fetus, paternal investigations, plasminogen activator inhibitor polymorphism)
4To what extent do pre-existing medical conditions cause miscarriage? (eg, vitamin deficiencies, diabetes, previous infertility, endometriosis, polycystic ovarian syndrome, menstrual irregularities, cervical factors, uterine anomalies, polyps, immunological factors or previous pregnancy complications for example, caesarean section or preterm birth)
5What types of emotional support are effective in preventing or treating women or their partners after a miscarriage?
6Do lifestyle factors (diet, stress, exercise, weight, alcohol, sexual activity, smoking, night shifts or flying) cause miscarriage?
7To what extent do genetic and chromosomal abnormalities in the fetus cause miscarriage?
8What preconception tests or interventions prevent miscarriage? (eg, vitamin supplements, folic acid, dehydroepiandrosterone, co-enzyme Q-10 or bariatric surgery)
9What are the appropriate investigations for women after one, two, or three or more miscarriages?
10What male factors contribute towards the cause of miscarriage?
  • TNF, tumour necrosis factor.