Table 3

HRs for cardiovascular mortality at year 5

VariableNumber of cardiovascular Deaths (%)Univariable HRs (95% CI)Adjusted HRs (95% CI)
Model 1Model 2Model 3
FGF23 (pg/mL)
 <257 (7.0)1 (ref)1 (ref)1 (ref)1 (ref)
 25–5154 (5.0)0.71 (0.32 to 1.57)0.52 (0.24 to 1.15)0.61 (0.28 to 1.36)0.63 (0.28 to 1.41)
 52–7021 (6.6)0.97 (0.41 to 2.27)0.47 (0.19 to 1.12)0.56 (0.23 to 1.35)0.57 (0.24 to 1.37)
 >7019 (12.2)1.85 (0.78 to 4.41)0.74 (0.30 to 1.84)0.78 (0.31 to 1.93)0.79 (0.32 to 1.97)
PTH (pg/mL)
 <3513 (3.0)1 (ref)1 (ref)1 (ref)1 (ref)
 35–6548 (6.0)2.02 (1.09 to 3.72)*1.55 (0.84 to 2.87)1.49 (0.80 to 2.77)1.50 (0.80 to 2.79)
 66–9520 (7.0)2.57 (1.28 to 5.16)*1.50 (0.74 to 3.04)1.36 (0.66 to 2.79)1.36 (0.66 to 2.83)
 >9520 (14.7)5.60 (2.79 to 11.26)*2.55 (1.25 to 5.21)*2.10 (1.02 to 4.30)*2.11 (1.00 to 4.47)
25(OH)Vit D (nmol/L)
 <2512 (11.5)2.67 (1.29 to 5.55)*2.13 (1.02 to 4.45)*1.83 (0.86 to 3.87)1.71 (0.77 to 3.78)
 25–5041 (6.3)1.31 (0.75 to 2.28)1.15 (0.66 to 2.01)1.05 (0.60 to 1.85)1.02 (0.57 to 1.82)
 51–7530 (5.4)1.09 (0.61 to 1.95)1.09 (0.66 to 1.95)1.07 (0.59 to 1.93)1.05 (0.58 to 1.91)
 >7518 (5.0)1 (ref)1 (ref)1 (ref)1 (ref)
  • Model 1 – adjusted HRs for age, baseline eGFR, gender and uACR

  • Model 2 – adjusted HRs for variables in model 1 plus diabetes, previous cardiovascular disease, haemoglobin, serum bicarbonate and serum albumin

  • Model 3 – HRs adjusted for variables included in model 2 plus vitamin D insufficiency, elevated PTH and elevated FGF23 as appropriate

  • *p<0.05

  • eGFR, estimated glomerular filtration rate; FGF, fibroblast growth factor; PTH, parathyroid hormone; uACR, urinary albumin to creatinine ratio; 25(OH)Vit D, 25-hydroxy-Vitamin D.