Table 2

Multivariate analysis of the interaction between IAH and clinical symptoms

SymptomVariableHR 95% CIp Value
SepsisIAH3.642.50 to 5.29<0.001*
Sepsis1.300.94 to 1.810.112
Interaction0.520.25 to 1.070.076
NeurologicalIAH3.272.25 to 4.76<0.001*
Neurological0.990.67 to 1.460.95
Interaction2.311.09 to 4.900.029*
CVDIAH3.302.26 to 4.82<0.001*
CVD0.780.47 to 1.300.34
Interaction3.031.29 to 7.150.011*
RespiratoryIAH3.692.49 to 5.47<0.001*
Respiratory failure1.380.96 to 1.980.079
Interaction0.730.37 to 1.480.39
AKIIAH3.642.51 to 5.30<0.001*
AKI1.010.71 to 1.420.97
Interaction0.560.27 to 1.170.12
  • *p<0.05.

  • Adjusted for age, gender, APACHE-II score, renal replacement therapy and mechanical ventilation.

  • AKI, acute kidney injury; CVD, cerebrovascular disease; IAH, intensive care unit-acquired hypernatraemia.