Table 2

Association (β 95% CI) between antidepressant use and annual weight gain

Non-user1–2 prescriptions/year>2 prescriptions/yearp Value
Any antidepressant
  n1934188212
 Baseline weight (kg), mean (SD)80.0 (17.0)77.1 (16.5)81.3 (19.1)
 Follow-up weight (kg), mean (SD)80.6 (17.3)78.0 (17.2)82.5 (19.6)
  Annual weight change (kg), mean (SD)0.12 (1.32)0.18 (1.54)0.28 (1.99)
   Model 1*Ref0.15(−0.06 to 0.36)0.22 (0.02 to 0.42)0.022
   Model 2†Ref0.18(−0.04 to 0.40)0.25 (0.04 to 0.46)0.009
   Model 3‡Ref0.11(−0.11 to 0.34)0.22 (0.00 to 0.44)0.044
SSRIs
  n2109114111
 Baseline weight (kg), mean (SD)79.8 (17.0)79.7 (18.2)82.2 (19.1)
 Follow-up weight (kg), mean (SD)80.3 (17.3)81.2 (18.0)84.9 (21.2)
 Annual weight change (kg), mean (SD)0.11 (1.33)0.38 (2.11)0.61 (1.89)
   Model 1*Ref0.30 (0.04 to 0.57)0.53 (0.27 to 0.80)<0.001
   Model 2†Ref0.30 (0.03 to 0.58)0.58 (0.30 to 0.85)<0.001
   Model 3‡Ref0.30 (0.01 to 0.58)0.48 (0.20 to 0.76)<0.001
TCAs
  n22127943
 Baseline weight (kg), mean (SD)80.1 (17.2)76.3 (17.8)77.3 (15.9)
 Follow-up weight (kg), mean (SD)80.8 (17.5)75.5 (17.3)77.3 (16.4)
 Annual weight change (kg), mean (SD)0.16 (1.40)−0.13 (1.61)−0.01 (1.32)
   Model 1*Ref−0.12(−0.44 to 0.19)0.06(−0.36 to 0.49)0.717
   Model 2†Ref−0.11(−0.44 to 0.22)0.05(−0.39 to 0.50)0.704
   Model 3‡Ref0.02(−0.31 to 0.36)0.03(−0.46 to 0.52)0.908
Other antidepressants
  n22105767
 Baseline weight (kg), mean (SD)79.8 (17.0)80.0 (18.7)82.9 (20.5)
 Follow-up weight (kg), mean (SD)80.4 (17.4)81.3 (17.6)83.4 (21.2)
 Annual weight change (kg), mean (SD)0.14 (1.37)0.35 (1.88)0.12 (2.08)
   Model 1*Ref0.23(−0.13 to 0.60)−0.04(−0.38 to 0.29)0.844
   Model 2†Ref0.32(−0.05 to 0.70)−0.01(−0.36 to 0.35)0.505
   Model 3‡Ref0.42 (0.03 to 0.80)−0.19(−0.56 to 0.19)0.926
  • *Model 1 adjusted for age and gender.

  • †Model 2 further adjusted for baseline income, smoking, physical activity, follow-up duration.

  • ‡Model 3 further adjusted for depression status at baseline and follow-up, dietary patterns (continuous).

  • SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant.