(b) Patients with fixed perfusion defects
Univariate analysis	1.49	0.31	1.68	0.18	1.24	0.72	1.29	0.66
Adjusted for clinical variables
Age	1.50	0.30	1.75	0.16	1.26	0.70	1.28	0.67
Gender	1.41	0.39	1.60	0.22	1.22	0.74	1.30	0.66
Age, gender	1.44	0.36	1.69	0.19	1.26	0.71	1.30	0.66
DM	1.42	0.39	1.63	0.23	1.19	0.78	1.26	0.40
Known CAD	1.49	0.31	1.68	0.17	1.20	0.76	1.28	0.67
Previous MI	1.50	0.31	1.69	0.17	1.24	0.72	1.29	0.66
Previous PCI	1.52	0.29	1.70	0.16	1.26	0.70	1.29	0.65
CAD category*	1.55	0.27	1.76	0.15	1.28	0.68	1.31	0.64
CAD category*, previous MI	1.56	0.26	1.77	0.14	1.29	0.67	1.32	0.64
CAD category*, previous MI, aspirin, beta blocker, lipid lowering	1.39	0.41	1.58	0.25	1.28	0.69	1.31	0.66
Gender, CAD category*, previous MI, aspirin, beta blocker, lipid lowering	1.34	0.47	1.51	0.30	1.27	0.69	1.32	0.65
Adjusted for angiographic variables
CCS score (n=223/115)	1.61	0.27	1.93	0.09	0.82	0.75	0.87	0.80
Number of stenotic vessels (n=210/108)	2.35	0.09	2.67	0.06	0.74	0.65	0.77	0.69
CCS score, number of stenotic vessels (n=210/108)	1.76	0.28	2.27	0.07	0.64	0.51	0.73	0.58
Adjusted for scintigraphic variables
At-rest LVEF (n=648/147)	0.85	0.87	1.00	1.00	–^†	–^†	–^†	–^†
Post-stress LVEF (n=687/123)	0.59	0.61	0.72	0.73	–^†	–^†	–^†	–^†
Size of defects	1.23	0.61	1.38	0.43	1.00	1.00	1.08	0.90
Adjusted for selected variables of all types
Gender, CAD category*, previous MI, aspirin, beta blocker, lipid lowering, CCS score (n=223/115)	1.54	0.38	1.99	0.13	0.89	0.86	0.94	0.93
Gender, CAD category*, previous MI, aspirin, beta blocker, lipid lowering, number of stenotic vessels (n=210/108)	3.68	0.06	4.31	0.10	0.90	0.90	0.85	0.89
Gender, CAD category*, previous MI, aspirin, beta blocker, lipid lowering, CCS score, number of stenotic vessels (n=210/108)	3.05	0.11	4.37	0.07	0.84	0.83	0.92	0.94

↵*In order to reduce the number of covariates, and because of correlation between CAD and previous revascularisation, a CAD category variable was generated, taking into account the history of both CAD and previous revascularisation: 1 = suspected CAD; 2 = known CAD with no previous revascularisation; 3 = known CAD with previous revascularisation.
↵†Fitting of Cox model indicated complete separation; hence, no results could be presented.
ACD, all-cause death; CAD, coronary artery disease; CCS, Canadian Cardiovascular Society; CD, cardiac death; CSHR, cause-specific HR; DM, diabetes mellitus; LVEF, left ventricular ejection fraction; MI, myocardial infarction; MPS, myocardial perfusion scintigraphy; PCI, percutaneous coronary intervention; SDHR, subdistribution HR.