Table 2

Outcome measurements

Health measurements
 Depression questionnaireCentre for Epidemiologic Studies of Depression scale
 Anxiety questionnaireAnxiety subscale of the Hospital Anxiety and Depression Scale
 Health statusSaint George Respiratory Questionnaire, COPD Assessment Test
 DyspnoeaModified Medial Research Council dyspnoea scale
Haematology and blood chemistry analyses
 Complete blood countRed and white blood cells, platelets
 Comprehensive metabolic panelGlucose, calcium, albumin and total blood protein, blood urea nitrogen, creatinine, alkaline phosphatase, alanine amino transferase, aspartate amino transferase and bilirubin
 Lipid panelTotal cholesterol, high-density lipoproteins cholesterol, low-density lipoproteins cholesterol and triglycerides
Lung function
 Spirometry pre–postbronchodilator FEV1, FVC, FEV1/FVC, IC, reversibility
 Pulmonary plethysmography RV, TLC, FRC
 Diffusion capacity of the lung for carbon monoxide
Heart function
 Resting echocardiographyMeasurement of diastolic and systolic function
 Stress echocardiographyMeasurement of systolic function and potential myocardial ischemia
Chest CTMeasurement of airway characteristics
Quantification of emphysema
Mid-tight CTMeasurements of right mid-tight area
Exercise capacitySupervised, encouraged 6-min walk test
Cardiopulmonary exercise test on a cycle ergometer
 Peak VO2, VCO2, VESymptom-limited incremental cycle exercise test
 Iso-time and iso-work measurementsConstant work rate cycle endurance test
Physical activity
 Triaxial accelerometer measurementStep count
Spent physical activity time per day
Physical activity level
  • COPD, chronic obstructive pulmonary disease; IC, inspiratory capacity; FEV1, forced expiratory volume in 1 s; FRC, functional residual capacity; FVC, forced vital capacity; RV, residual volume; TLC, total lung capacity; VCO2, carbon dioxide production; VE, minute ventilation; VO2, oxygen consumption.