Table 2

HRs for all-cause and cardiovascular mortality by baseline and time-averaged exposure categories

All-cause mortalityCardiovascular-mortality
GNRIPhosphorusBaselineTime-averagedBaselineTime-averaged
Incidence rate*HR†95% CIHR‡95% CIIncidence rate*HR†95% CIHR‡95% CI
Low-middleLow12.13.432.11 to 5.584.282.66 to 6.884.72.391.33 to 4.303.041.62 to 5.67
Middle5.51.931.33 to 2.792.121.51 to 2.962.61.570.95 to 2.591.801.20 to 2.70
High4.62.181.41 to 3.372.201.45 to 3.352.51.971.07 to 3.652.351.43 to 3.84
HighLow3.31.140.49 to 2.700.930.22 to 3.871.61.010.32 to 3.240.830.12 to 5.57
Middle2.11reference1reference1.41reference1reference
High2.61.591.03 to 2.451.661.01 to 2.731.81.710.94 to 3.112.021.18 to 3.45
  • Low-middle GNRI: < highest tertile of GNRI; high GNRI: ≥ highest tertile of GNRI; low phosphorus: <3.5 mg/dL; middle phosphorus: 3.5 to <6.0 mg/dL; high phosphorus: ≥6.0 mg/dL.

  • *Incidence rate per 100 person-years.

  • †Cox proportional hazards model adjusted for age, sex, time on dialysis, 11 comorbid conditions listed in table 1, single-pool Kt/V, oral or intravenous VDRA use, phosphate binder use and DOPPS phase.

  • ‡Time-dependent Cox proportional hazards model adjusted for age, sex, time on dialysis, 11 comorbid conditions listed in table 1, single-pool Kt/V, oral or intravenous VDRA use, phosphate binder use, and DOPPS phase.

  • DOPPS, the Dialysis Outcomes and Practice Pattern Study; GNRI, Geriatric Nutritional Risk Index; VDRA, vitamin D receptor activator.