Table 1

Prospective studies examining the effects of prenatal alcohol exposure on pregnancy outcomes (studies included in the meta-analysis)

Study (year)CountryEventTotal numberOutcomesTiming of exposureAge at outcome assessment (child)Adjusted (yes/no)
Lundsberg (2015)22USA191
315
274
3907Birth weight (<2500 g)
SGA (<10th percentile)
Preterm birth (<37 weeks)
First trimesterBirthYes
Nykjaer (2014)49UK



23
535Birth weight (g)
Customised birth centile
SGA (<10th centile)
Low birth weight (<2500 g)
Preterm birth (<37 weeks)
First trimesterBirthYes
Niclasen (2014)50Denmark10 64910% with highest problem scores, SDQ, parent report
Boys internalising behaviour
Girls internalising behaviour
Boys externalising behaviour
Girls externalising behaviour
Entire pregnancy7 yearsYes
Miyake33Japan126
185

202
1493Preterm birth (<37 weeks)
SGA (<10th percentile)
Adjusted mean birth weight
Low birth weight (<2500 g)
Between 5th and 39th weeks of pregnancy0–11 monthsYes
McCarthy23New Zealand, Australia, UK and Ireland
325
150
3166Birth weight
SGA (<10th percentile)
Preterm birth (<37 weeks)
First trimesterBirthyes
Salihu27USAPreterm birth (<37 weeks)
SGA (<10th percentile)
Within the gestational age range 20–44 weeksBirthYes
Robinson34Australia2021335Clinically significant problems (T score ≥60), CBCL
Parent report
Internalising behaviour
Externalising behaviour
Second trimester2–14 years inclusiveYes
Jaddoe51Holland; UK

4132Low birth weight
SGA (weight <−2 SD scores)
Preterm birth (<37 weeks)
Birth weight
Late pregnancyBirthYes
Sayal52UK10 32310% with highest problem scores, SDQ parent report Hyperactivity—externalisingFirst trimester7.75 yearsYes
Sayal52UK10 32310% with highest problem scores, SDQ parent report Conduct problems—externalisingFirst trimester7.75 yearsYes
Albertsen24Denmark148829 463Preterm birth (<37 weeks)
Moderate preterm birth (32–37 weeks)
Very preterm birth (<32 weeks)
During pregnancyBirthYes
Lundsberg53USA2062SGA (lowest 10th percentile)
Low birth weight
Preterm delivery (<37 weeks)
First trimesterBirthYes
Passaro54UK8886Birth weight (g)At booking for antenatal care (before 24 weeks gestation)BirthYes
Shu55USA638Birth weight (g)Throughout pregnancy (12.9, 28 and 36 weeks gestation)BirthYes
Peacock26UK64901Preterm birth (<37 weeks)At booking for antenatal care (before 24 weeks gestation)BirthNo
Olsen56Denmark8772Birth weight (<2500 g)During the first 36 weeks gestationBirthyes
Brooke21UK1140Birth weight (g)Early pregnancyBirthyes
  • CBCL, Child Behaviour Checklist; SDQ, Strengths and Difficulties Questionnaire; SGA, small for gestation age.