Time trends in age-specific and standardised 5-year relative survival for lymphomas by WHO subtype in Manitoba, Canada
| Classification | Sex | Age group | 1984–1993 | 1994–2003 | 2004–2013 | Difference between 1984–1993 and 2004–2013 | p Value for time trend test | ||||||
| N | Relative survival | SE | N | Relative survival | SE | N | Relative survival | SE | |||||
| HL | Male | 20–29 | 45 | 86.6 | 5.7 | 23 | 87.1 | 7.0 | 39 | 100.0 | 0 | 13.4 | 0.074 |
| 30–54 | 46 | 91.6 | 4.3 | 64 | 91.1 | 3.7 | 58 | 89.6 | 4.8 | −2.0 | 0.009 | ||
| 55+ | 44 | 35.9 | 9.6 | 47 | 53.1 | 7.9 | 52 | 61.2 | 8.8 | 25.3 | 0.086 | ||
| Age-standardised | 135 | 73.9 | 3.8 | 134 | 77.8 | 3.6 | 149 | 82.7 | 3.1 | 8.8 | 0.081 | ||
| Female | 20–29 | 36 | 91.7 | 4.9 | 30 | 87.1 | 6.2 | 42 | 90.2 | 4.9 | −1.5 | 0.117 | |
| 30–54 | 37 | 88.6 | 5.9 | 32 | 91.6 | 5.2 | 37 | 96.9 | 4.0 | 8.3 | 0.081 | ||
| 55+ | 29 | 33.3 | 11.6 | 35 | 68.9 | 10.7 | 42 | 71.9 | 9.5 | 38.6 | 0.090 | ||
| Age-standardised | 102 | 77.6 | 3.9 | 97 | 86.2 | 3.9 | 121 | 83.8 | 3.4 | 6.2 | 0.404 | ||
| Overall | 20–29 | 81 | 89.0 | 3.8 | 53 | 83.9 | 5.7 | 81 | 94.6 | 2.8 | 5.6 | 0.203 | |
| 30–54 | 83 | 90.2 | 3.6 | 96 | 93.3 | 2.9 | 95 | 92.6 | 3.3 | 2.4 | 0.200 | ||
| 55+ | 73 | 34.7 | 7.4 | 82 | 64.0 | 7.2 | 93 | 66.1 | 6.5 | 31.4 | 0.093 | ||
| Age-standardised | 237 | 75.8 | 2.8 | 231 | 81.2 | 2.7 | 270 | 83.1 | 2.3 | 7.3 | 0.033 | ||
| NHL | Male | 20–54 | 285 | 64.4 | 3.4 | 453 | 66.0 | 2.3 | 417 | 77.2 | 2.3 | 12.8 | <0.0001 |
| 55–74 | 739 | 52.3 | 2.4 | 966 | 56.8 | 1.7 | 1279 | 65.1 | 1.7 | 12.7 | <0.0001 | ||
| 75+ | 388 | 32.2 | 3.9 | 655 | 38.7 | 2.5 | 787 | 43.9 | 2.7 | 11.7 | <0.0001 | ||
| Age-standardised | 1412 | 49.4 | 1.8 | 2074 | 51.3 | 1.4 | 2483 | 61.9 | 1.3 | 12.5 | <0.0001 | ||
| Female | 20–54 | 187 | 81.5 | 3.5 | 283 | 75.9 | 2.6 | 305 | 80.6 | 2.6 | −0.8 | <0.0001 | |
| 55–74 | 535 | 66.8 | 3.0 | 730 | 64.5 | 2.1 | 821 | 76.8 | 2.0 | 9.9 | <0.0001 | ||
| 75+ | 389 | 56.7 | 5.6 | 696 | 61.2 | 3.2 | 836 | 66.6 | 3.3 | 9.9 | <0.0001 | ||
| Age-standardised | 1111 | 66.9 | 2.2 | 1709 | 65.9 | 1.7 | 1962 | 74.7 | 1.4 | 7.8 | 0.005 | ||
| Overall | 20–54 | 472 | 70.9 | 2.5 | 736 | 67.2 | 2.0 | 722 | 78.6 | 1.8 | 7.7 | 0.002 | |
| 55–74 | 1,274 | 58.4 | 1.9 | 1696 | 59.1 | 1.6 | 2100 | 69.7 | 1.3 | 11.3 | <0.0001 | ||
| 75+ | 777 | 43.0 | 3.3 | 1351 | 47.3 | 2.4 | 1623 | 54.9 | 2.1 | 12.0 | <0.0001 | ||
| Age-standardised | 2,523 | 57.0 | 1.4 | 3783 | 57.9 | 1.1 | 4445 | 67.5 | 0.9 | 10.0 | <0.0001 | ||
| CLL/SLL | Male | 20–54 | 53 | 87.0 | 5.6 | 68 | 88.7 | 4.9 | 66 | 90.8 | 4.1 | 3.7 | 0.364 |
| 55–74 | 257 | 67.9 | 3.9 | 286 | 78.7 | 3.5 | 341 | 83.5 | 2.8 | 15.6 | <0.0001 | ||
| 75+ | 125 | 49.1 | 7.7 | 196 | 48.1 | 6.0 | 242 | 64.2 | 5.2 | 15.1 | <0.0001 | ||
| Age-standardised | 435 | 67.8 | 3.1 | 550 | 73.7 | 2.6 | 649 | 80.9 | 2.1 | 13.1 | <0.0001 | ||
| Female | 20–54 | 29 | 97.4 | 5.3 | 42 | 96.3 | 4.1 | 43 | 92.6 | 5.1 | −4.8 | <0.0001 | |
| 55–74 | 129 | 87.8 | 5.1 | 179 | 97.0 | 3.8 | 186 | 100.0 | 2.1 | 14.3 | <0.0001 | ||
| 75+ | 104 | 70.8 | 11.6 | 209 | 87.6 | 7.6 | 182 | 100.0 | 6.8 | 44.8 | <0.0001 | ||
| Age-standardised | 262 | 86.0 | 3.6 | 430 | 94.3 | 2.9 | 411 | 100.0 | 2.3 | 14.0 | <0.0001 | ||
| Overall | 20–54 | 82 | 90.9 | 4.1 | 110 | 91.1 | 3.6 | 109 | 91.5 | 3.2 | 0.6 | 0.693 | |
| 55–74 | 386 | 74.5 | 3.1 | 465 | 85.7 | 2.6 | 527 | 90.5 | 2.0 | 16.0 | <0.0001 | ||
| 75+ | 229 | 57.4 | 6.5 | 405 | 66.9 | 4.9 | 424 | 85.1 | 4.3 | 27.7 | <0.0001 | ||
| Age-standardised | 697 | 74.3 | 2.3 | 980 | 82.6 | 2.0 | 1060 | 89.3 | 1.7 | 12.0 | <0.0001 | ||
| DLBCL | Male | 20–54 | 54 | 55.3 | 7.8 | 80 | 51.7 | 6.1 | 103 | 69.3 | 5.2 | 14.1 | 0.036 |
| 55–74 | 103 | 40.5 | 5.9 | 162 | 43.8 | 4.6 | 262 | 49.4 | 3.8 | 8.8 | 0.009 | ||
| 75+ | 42 | 14.0 | 7.2 | 114 | 32.4 | 6.2 | 172 | 28.4 | 5.1 | 14.4 | 0.007 | ||
| Age-standardised | 199 | 35.6 | 4.1 | 356 | 42.4 | 3.1 | 537 | 47.4 | 2.6 | 11.8 | 0.002 | ||
| Female | 20–54 | 27 | 78.7 | 9.0 | 69 | 72.9 | 6.2 | 94 | 75.8 | 5.1 | −2.9 | 0.003 | |
| 55–74 | 83 | 54.8 | 7.3 | 143 | 44.4 | 5.1 | 204 | 67.6 | 4.1 | 12.8 | 0.002 | ||
| 75+ | 61 | 52.5 | 14.1 | 123 | 44.1 | 8.2 | 208 | 47.1 | 5.9 | −5.4 | <0.0001 | ||
| Age-standardised | 171 | 54.9 | 5.6 | 335 | 49.6 | 3.6 | 506 | 63.5 | 2.8 | 8.6 | 0.002 | ||
| Overall | 20–54 | 81 | 62.0 | 6.3 | 149 | 61.4 | 4.4 | 197 | 72.5 | 3.6 | 10.5 | 0.019 | |
| 55–74 | 186 | 46.5 | 4.7 | 305 | 43.9 | 3.4 | 466 | 57.4 | 2.8 | 10.9 | 0.0002 | ||
| 75+ | 103 | 32.4 | 8.2 | 237 | 38.4 | 5.1 | 380 | 38.7 | 4.0 | 6.3 | <0.0001 | ||
| Age-standardised | 370 | 44.7 | 3.4 | 691 | 45.9 | 2.4 | 043 | 55.0 | 2.0 | 10.3 | <0.0001 | ||
| FL | Male | 20–54 | 64 | 70.3 | 6.9 | 116 | 79.1 | 4.6 | 77 | 94.5 | 3.2 | 24.2 | <0.0001 |
| 55–74 | 88 | 56.3 | 7.2 | 116 | 56.3 | 6.2 | 172 | 83.6 | 3.6 | 27.3 | <0.0001 | ||
| 75+ | 35 | 30.7 | 12.8 | 43 | 35.5 | 12.6 | 50 | 59.7 | 14.2 | 29.0 | <0.0001 | ||
| Age-standardised | 187 | 52.4 | 5.6 | 275 | 55.6 | 4.8 | 299 | 80.5 | 3.7 | 27.1 | <0.0001 | ||
| Female | 20–54 | 64 | 91.3 | 4.6 | 79 | 67.8 | 6.5 | 65 | 94.1 | 3.7 | 2.8 | <0.0001 | |
| 55–74 | 104 | 72.3 | 6.5 | 121 | 70.6 | 5.7 | 128 | 84.6 | 4.7 | 12.2 | <0.0001 | ||
| 75+ | 31 | 80.1 | 20.3 | 65 | 96.2 | 11.8 | 88 | 105.6 | 9.7 | 25.5 | <0.0001 | ||
| Age-standardised | 199 | 77.8 | 5.8 | 265 | 75.6 | 4.2 | 281 | 91.9 | 3.6 | 14.1 | 0.086 | ||
| Overall | 20–54 | 128 | 80.3 | 4.4 | 195 | 74.5 | 3.8 | 142 | 94.3 | 2.4 | 14.0 | 0.001 | |
| 55–74 | 192 | 65.4 | 4.9 | 237 | 63.9 | 4.2 | 300 | 84.1 | 2.9 | 18.7 | <0.0001 | ||
| 75+ | 66 | 52.4 | 11.7 | 108 | 72.0 | 9.2 | 138 | 90.1 | 8.2 | 37.7 | <0.0001 | ||
| Age-standardised | 386 | 65.3 | 3.9 | 540 | 67.2 | 3.2 | 580 | 87.6 | 2.5 | 22.3 | <0.0001 | ||
| PCN | Male | 20–54 | 46 | 37.4 | 9.1 | 50 | 41.6 | 8.3 | 52 | 47.8 | 8.1 | 10.5 | 0.758 |
| 55–74 | 168 | 27.2 | 4.4 | 177 | 29.4 | 4.3 | 222 | 39.7 | 4.3 | 12.5 | 0.014 | ||
| 75+ | 124 | 19.1 | 5.5 | 139 | 18.5 | 5.1 | 157 | 14.0 | 4.1 | −5.1 | 0.019 | ||
| Age-standardised | 338 | 26.6 | 3.3 | 366 | 29.9 | 3.1 | 431 | 36.2 | 2.9 | 9.6 | 0.018 | ||
| Female | 20–54 | 21 | 51.0 | 13.5 | 25 | 50.0 | 13.5 | 30 | 61.2 | 11.3 | 10.1 | 0.012 | |
| 55–74 | 128 | 33.3 | 5.8 | 120 | 29.9 | 5.9 | 135 | 45.0 | 5.9 | 11.7 | 0.018 | ||
| 75+ | 132 | 43.4 | 8.4 | 156 | 22.3 | 6.0 | 174 | 26.1 | 5.5 | −17.3 | 0.143 | ||
| Age-standardised | 281 | 39.8 | 4.5 | 301 | 31.0 | 4.2 | 339 | 43.5 | 4.0 | 3.7 | 0.533 | ||
| Overall | 20–54 | 67 | 41.6 | 7.6 | 75 | 43.7 | 7.1 | 82 | 52.7 | 6.6 | 11.1 | 0.797 | |
| 55–74 | 296 | 29.8 | 3.5 | 297 | 29.8 | 3.5 | 357 | 41.6 | 3.5 | 11.8 | 0.015 | ||
| 75+ | 256 | 30.9 | 5.0 | 295 | 20.5 | 3.9 | 331 | 20.0 | 3.4 | −10.9 | 0.165 | ||
| Age-standardised | 619 | 32.0 | 2.8 | 667 | 31.2 | 2.5 | 770 | 39.4 | 2.4 | 7.4 | 0.189 | ||
CLL/SLL, chronic/small lymphocytic leukaemia/lymphoma; DLBCL, diffuse large B cell lymphoma; FL, follicular lymphoma; HL, Hodgkin lymphoma; NHL, non-Hodgkin lymphoma; PCN, plasma cell neoplasm.