Table 3

Comparison of spirometric prediction of mortality among subjects with and without prior disease history at entry in UK Biobank

Condition at entry Cause of death Biobank age 40–69 years, white lifelong non-smokers without a history of the condition at entry Biobank age 40–69 years, white lifelong non-smokers with a history of the condition at entry
Total N (deaths) zFEV1, HR (95% CI) zFVC, HR (95%CI) Total N (deaths) zFEV1, HR (95% CI) zFVC, HR (95% CI)
Respiratory diseaseAll causes130 798 (2081)1.21 (1.16 to 1.26)1.22 (1.17 to 1.27)18 545 (320)1.23 (1.12 to 1.35)1.33 (1.21 to 1.47)
Circulatory diseaseCirculatory disease109 141 (189)1.40 (1.23 to 1.59)1.40 (1.23 to 1.60)40 202 (242)1.35 (1.20 to 1.51)1.43 (1.27 to 1.60)
CancerCancer137 742 (978)1.05 (0.99 to 1.11)1.06 (1.00 to 1.12)11 601 (557)1.10 (1.02 to 1.18)1.13 (1.04 to 1.22)
  • Spirometric indices (FEV1 and FVC) are modelled as z-scores derived from the Global Lung Initiative 2012 reference equations for whites. All HRs are expressed per unit decrement in z-score, adjusted for age, sex, height, socioeconomic status and geographical region (recruitment centre).

  • FEV1, one-second forced expiratory volume; FVC, forced vital capacity; z, z-score.