Table 2

Sensitivity analyses around the primary analyses

ScenarioDesaturation, mildDesaturation, severeApnoeaBradycardiaHypotensionAssisted ventilationSupplemental oxygen
Base case (all studies)0.77
(0.67, 0.89)
0.59
(0.43, 0.81)
1.17
(0.72, 1.89)
1.16
(0.88, 1.54)
1.02
(0.78, 1.33)
0.47
(0.23, 0.95)
0.93
(0.75, 1.15)
 High-quality studies0.75
(0.62, 0.92)
0.57
(0.36, 0.92)
0.89
(0.64, 1.23)
1.26
(0.80, 1.99)
0.97
(0.73, 1.30)
0.56
(0.27, 1.20)
0.98
(0.79, 1.23)
 Moderate sedation0.80
(0.60, 1.07)
0.99
(0.69, 1.42)
 USA only0.80
(0.64, 0.99)
0.59
(0.26, 1.30)
0.89
(0.64, 1.23)
1.04
(0.57, 1.88)
 Europe only0.77
(0.63, 0.96)
0.61
(0.44, 0.84)
2.83
(0.12, 67.30)
1.18
(0.86, 1.61)
0.90
(0.66, 1.24)
0.49
(0.23, 1.03)
0.91
(0.67, 1.25)
 Studies with potential bias excluded0.78
(0.64, 0.95)
0.65
(0.37, 1.14)
0.99
(0.69, 1.42)
1.26
(0.80, 1.99)
0.92
(0.68, 1.25)
0.56
(0.27, 1.20)
1.16
(0.95, 1.41)
 Studies in paediatrics excluded0.78
(0.67, 0.89)
0.59
(0.43, 0.81)
1.29
(0.75, 2.23)
1.16
(0.88, 1.54)
1.02
(0.78, 1.33)
0.47
(0.23, 0.95)
0.92
(0.74, 1.14)
 Gender-specific studies excluded0.76
(0.66, 0.89)
0.59
(0.41, 0.84)
1.17
(0.72, 1.89)
1.18
(0.84, 1.65)
1.03
(0.75, 1.41)
0.49
(0.23, 1.03)
0.84
(0.68, 1.03)
 Studies with mean age >30 years0.75
(0.65, 0.87)
0.56
(0.41, 0.78)
1.29
(0.75, 2.23)
1.16
(0.88, 1.54)
1.02
(0.78, 1.33)
0.47
(0.23, 0.95)
0.87
(0.71, 1.07)
  • The reported treatment effect is the risk ratio (95% CI), except for assisted ventilation where the Peto OR (95% CI) is used.