Table 3

Trials comparing glibenclamide (glyburide) to insulin

First authorYearLocationNoDiagnostic test and glucose thresholds used to diagnose GDMScreening strategy*Outcome
Anjalakshi67 2007India2375 g OGTT 2 hours >7.8Universal OGTTBW
Bertini68 2005Brazil7075 g OGTT fasting >6.1 or 2 hours >7.8Not reportedBW, C-section, Apgar 5 min, GA at birth, LGA
Lain69 2009USA99100 g OGTT two or more: fasting >5.3, 1 hour >8.6 or 2 hours >8.650 g >7.5BW, GA at birth, LGA, macrosomia
Langer70 2000USA404100 g OGTT fasting >5.3 to <7.850 g OGCT>7.3BW, C-section, GA at birth, LGA, macrosomia, hypoglycaemia, NICU admission, pre-eclampsia
Mirzamoradi32 2015Iran96Glucose load not reported; OGTT two or more: fasting >5.3, 1 hour >10.0, 2 hours >8.3Universal OGTTBW, C-section, GA at birth, NICU admission, hypoglycaemia, pre-eclampsia
Mukhopadhyay71 2012India6075 g OGTT 2 hours >7.8No screeningBW, GA at birth, LGA, hypoglycaemia
Ogunyemi72 2007USA97Not reportedNot reportedBW, C-section, GA at birth, hypoglycaemia,
Silva73 2007Brazil6875 g OGTT fasting >6.1 or 2 hours >7.8No screeningBW, C-section, LGA, macrosomia,
Tempe74 2013India64100 g OGTT two or more: fasting >5.3, 1 hour >10.0, 2 hours >8.6 or 3 hours >7.850 g OGCT >7.2BW, GA birth, macrosomia, hypoglycaemia, NICU admission, pre-eclampsia, preterm birth
  • *It is assumed unless otherwise reported that the screening strategy advocated by the criteria used was adhered to.

  • BW, birth weight; C-section, caesarean section; GA, gestational age; GDM, gestational diabetes mellitus; LGA, large for gestational age; NICU, neonatal intensive care unit.