Table 2

Baseline characteristics of the cohort of the diabetic patients with stable CAD according to serum fibrinogen levels at baseline

VariablesFibrinogen tertiles (g/L)p-Value
Low (≤2.91)(n=476)Middle (2.91–3.51)(n=476)High (≥3.51)(n=470)
Age (years)58.65±9.6659.16±9.6959.91±10.220.142
BMI (kg/m2)26.21±3.0826.18±2.9226.30±3.580.838
Gender, men, % (n)78.4 (373)68.5 (326)65.3 (307) <0.001
Dyslipidaemia, % (n)80.5 (383)81.1 (385)81.9 (385)0.848
Hypertension, % (n)71.4 (340)72.0 (342)76.4 (359)0.170
Current smoking, % (n)53.2 (253)53.3 (253)48.3 (227)0.219
SBP (mm Hg)126.82±15.45127.57±17.08127.58±17.040.723
DBP (mm Hg)76.60±10.0077.07±10.2676.64±10.150.731
TC (mmol/L)3.86±1.054.17±1.174.27±1.24 <0.001
HDL-C (mmol/L)1.02±0.251.03±0.261.03±0.300.739
LDL-C (mmol/L)2.28±0.892.52±0.942.60±1.01 <0.001
Triglycerides (mmol/L)1.57 (1.12, 2.13)1.60 (1.24, 2.34)1.54 (1.19, 2.17)0.092
HbA1C (%)7.23±1.237.52±1.287.84±1.46 <0.001
Glucose (mmol/L)6.81±2.107.22±0.327.58±2.43 <0.001
hs-CRP, mg/L0.88 (0.52, 1.45)1.54 (0.82, 2.71)3.64 (1.83, 8.34) <0.001
Uric acid (µmol/L)340.93±95.56339.06±86.97346.60±98.620.441
CVD events, % (n)5.0 (24)5.7 (27)9.6 (45) 0.011
Duration of diabetes (years)9.03±6.828.89±6.0310.83±6.830.356
Gensini score28 (19, 49)30 (16, 56)33 (17, 61)0.315
Fibrinogen (g/L)2.55±0.313.21±0.164.20±0.74 <0.001
  • Data are presented as mean ± SD, median (25th, 75th percentiles) or % (n). CVD events: myocardial infarction, cardiac death, myocardial revascularisation and fatal or non-fatal stroke.

  • BMI, body mass index; CAD, coronary artery disease; CVD, cardiovascular disease events: myocardial infarction, cardiac death, myocardial revascularisation and fatal or non-fatal stroke; DBP, diastolic blood pressure; HbA1c, glycosylated haemoglobin type A1C; HDL-C, high-density lipoprotein cholesterol; hs-CRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein cholesterol; SBP, systolic blood pressure; TC, total cholesterol.