Baseline characteristics of the cohort of the diabetic patients with stable CAD according to serum fibrinogen levels at baseline
| Variables | Fibrinogen tertiles (g/L) | p-Value | ||
| Low (≤2.91)(n=476) | Middle (2.91–3.51)(n=476) | High (≥3.51)(n=470) | ||
| Age (years) | 58.65±9.66 | 59.16±9.69 | 59.91±10.22 | 0.142 |
| BMI (kg/m2) | 26.21±3.08 | 26.18±2.92 | 26.30±3.58 | 0.838 |
| Gender, men, % (n) | 78.4 (373) | 68.5 (326) | 65.3 (307) | <0.001 |
| Dyslipidaemia, % (n) | 80.5 (383) | 81.1 (385) | 81.9 (385) | 0.848 |
| Hypertension, % (n) | 71.4 (340) | 72.0 (342) | 76.4 (359) | 0.170 |
| Current smoking, % (n) | 53.2 (253) | 53.3 (253) | 48.3 (227) | 0.219 |
| SBP (mm Hg) | 126.82±15.45 | 127.57±17.08 | 127.58±17.04 | 0.723 |
| DBP (mm Hg) | 76.60±10.00 | 77.07±10.26 | 76.64±10.15 | 0.731 |
| TC (mmol/L) | 3.86±1.05 | 4.17±1.17 | 4.27±1.24 | <0.001 |
| HDL-C (mmol/L) | 1.02±0.25 | 1.03±0.26 | 1.03±0.30 | 0.739 |
| LDL-C (mmol/L) | 2.28±0.89 | 2.52±0.94 | 2.60±1.01 | <0.001 |
| Triglycerides (mmol/L) | 1.57 (1.12, 2.13) | 1.60 (1.24, 2.34) | 1.54 (1.19, 2.17) | 0.092 |
| HbA1C (%) | 7.23±1.23 | 7.52±1.28 | 7.84±1.46 | <0.001 |
| Glucose (mmol/L) | 6.81±2.10 | 7.22±0.32 | 7.58±2.43 | <0.001 |
| hs-CRP, mg/L | 0.88 (0.52, 1.45) | 1.54 (0.82, 2.71) | 3.64 (1.83, 8.34) | <0.001 |
| Uric acid (µmol/L) | 340.93±95.56 | 339.06±86.97 | 346.60±98.62 | 0.441 |
| CVD events, % (n) | 5.0 (24) | 5.7 (27) | 9.6 (45) | 0.011 |
| Duration of diabetes (years) | 9.03±6.82 | 8.89±6.03 | 10.83±6.83 | 0.356 |
| Gensini score | 28 (19, 49) | 30 (16, 56) | 33 (17, 61) | 0.315 |
| Fibrinogen (g/L) | 2.55±0.31 | 3.21±0.16 | 4.20±0.74 | <0.001 |
Data are presented as mean ± SD, median (25th, 75th percentiles) or % (n). CVD events: myocardial infarction, cardiac death, myocardial revascularisation and fatal or non-fatal stroke.
BMI, body mass index; CAD, coronary artery disease; CVD, cardiovascular disease events: myocardial infarction, cardiac death, myocardial revascularisation and fatal or non-fatal stroke; DBP, diastolic blood pressure; HbA1c, glycosylated haemoglobin type A1C; HDL-C, high-density lipoprotein cholesterol; hs-CRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein cholesterol; SBP, systolic blood pressure; TC, total cholesterol.