Table 1

Outcome measures as reported by healthcare professionals for the outpatient setting (n=133) (six unclear outcomes, such as ‘cooperative’ and ‘eczema/atopy’, are not displayed)

Patient-related outcomes
DomainOutcomeTotal, n (%)
CryingDuration
Frequency
No crying
Intensity/severity of crying
83 (62)
10 (8)
 6 (5)
 3 (2)
DiscomfortDiscomfort of child/abdominal distension/pain35 (26)
SleepSleeping time (more/less)
Quality of sleep
25 (19)
 4 (3)
StoolNormal stools/stool consistency or frequency
Constipation/diarrhoea / blood in stool
Composition of intestinal microbiota
16 (12)
10 (8)
 1 (1)
FeedingFeeding (problems/pattern/volume)
Type of feeding (breastfed/formula +/− probiotics)
19 (14)
 8 (6)
GrowthThriving/Normal growth/Weight gain
Failure to thrive appearance/weight loss
18 (14)
 3 (2)
Gastrointestinal problemsVomiting (blood)/spitting/ regurgitation
Bloating/ gas passing
 8 (6)
 5 (4)
StressWell-being12 (9)
HospitalFewer consultations with healthcare professional
Hospital admission
10 (8)
 2 (2)
MedicationUse of probiotics/analgetics/(antireflux) medication
Safety/(no) side effects of medication
 7 (5)
 3 (2)
CostsCost of treatment 5 (4%)
Alarm symptomsEg, fever, rectal bleeding, signs of obstruction and recurrent infections 4 (3)
Other(No) adverse events/side effects
Missed organic cause
Harmful: doing any intervention/investigation
Effectivity/feasibility of treatment
Normal development
Any new symptom
 8 (6)
 6 (5)
 5 (4)
 2 (2)
 2 (2)
 1 (1)
Parent-related outcomes
Domain
Outcome
Total, n (%)
Quality of lifeQuality of life
Happy mother/ parents
Relationship between parents and infant
Restoring parents’ daily habits
Days absent from work for parents
Maternal depression
18 (14)
 7 (5)
 4 (3)
 3 (2)
 2 (2)
 2 (2)
Stress(Reduced) parental/family stress/anxiety
Relaxed/coping parents
More comfort mom
29 (22)
 6 (5)
 4 (3)
ReassuranceParental/maternal reassurance (+/− education) 9 (7)
Sleep(↑) sleep mother/parents 4 (3)
OtherParent satisfaction
No (physical) harm to infant
Parents/maternal opinion
Parents compliance
12 (9)
 6 (5)
 6 (5)
 1 (1)