Association of ACE genotype and salt intake with risk of hypertension
| ACE genotype | Quartiles of salt intake with median (IQR), g/day | ||||||||
| II (n=356) | ID (n=399) | DD (n=161) | p | Q1 | Q2 | Q3 | Q4 | p for linear trend | |
| Men | 128 | 148 | 66 | 11.9 (10.5–13.0) | 15.7 (14.8–16.4) | 18.3 (17.5–19.1) | 23.2 (21.4–25.9) | ||
| HTN, % | 46.9 | 49.3 | 54.6 | 48.8 | 47.1 | 44.2 | 57.7 | ||
| Crude OR (95% CI) | 1.00 | 1.10 (0.69 to 1.77) | 1.36 (0.75 to 2.47) | 0.327 | 1.00 | 0.93 (0.51 to 1.70) | 0.83 (0.46, 1.51) | 1.43 (0.78, 2.61) | 0.334 |
| Age-adjusted OR (95% CI) | 1.00 | 1.08 (0.66 to 1.78) | 1.31 (0.70 to 2.46) | 0.416 | 1.00 | 0.95 (0.50 to 1.79) | 0.88 (0.47, 1.66) | 1.79 (0.95, 3.39) | 0.105 |
| Multi-adjusted OR* (95% CI) | 1.00 | 1.01 (0.60 to 1.72) | 1.24 (0.64 to 2.40) | 0.567 | 1.00 | 0.98 (0.50 to 1.95) | 0.90 (0.46, 1.76) | 1.94 (0.97, 3.90) | 0.099 |
| Women | 228 | 251 | 95 | 10.4 (9.5–11.3) | 13.6 (12.8–14.3) | 16.5 (15.9–17.3) | 21.4 (19.6–24.7) | ||
| HTN, % | 39.9 | 35.1 | 28.4 | 28.5 | 36.4 | 35.0 | 43.8 | ||
| Crude OR (95% CI) | 1.00 | 0.81 (0.56 to 1.18) | 0.60 (0.36 to 1.00) | 0.048 | 1.00 | 1.44 (0.87 to 2.36) | 1.35 (0.82, 2.23) | 1.95 (1.20, 3.19) | 0.013 |
| Age-adjusted OR (95% CI) | 1.00 | 0.71 (0.46 to 1.09) | 0.50 (0.27 to 0.92) | 0.017 | 1.00 | 1.59 (0.89 to 2.85) | 1.25 (0.69, 2.26) | 1.87 (1.06, 3.30) | 0.073 |
| Multi-adjusted OR* (95% CI) | 1.00 | 0.71 (0.45 to 1.13) | 0.47 (0.25 to 0.87) | 0.014 | 1.00 | 1.36 (0.74 to 2.51) | 1.11 (0.59, 2.09) | 1.64 (0.89, 2.99) | 0.178 |
*Men adjusted for age, education, body mass index, drinking and fasting blood glucose; women adjusted for age, education, body mass index, occupation and fasting blood glucose.
HTN, hypertension prevalence.