Table 4

Associations between disease history and prescription of moderate-intensity or high-intensity statins

Year20042005200620072008200920102011
OR (95% CI)
History of coronary events2.04* 2.55* 2.83* 1.69* 2.39* 1.80*2.06*1.52*
(1.51 to  2.76)(1.80 to 3.59)(2.01 to 3.99)(1.22 to 2.35)(1.66 to 3.44)(1.34 to 2.42)(1.52 to 2.80)(1.13 to 2.03)
History of cerebrovascular events1.88* 1.61* 1.17* 1.40*1.66*1.61*
(1.56 to 2.25)(1.34 to 1.93)(0.99 to 1.38)(1.18 to 1.65)(1.40 to 1.96)(1.36 to 1.91)
History of diabetes1.17* 1.08* 1.010.88* 0.90* 0.83*0.85*0.83*
(1.08 to 1.27)(0.99 to 1.18)(0.93 to 1.09)(0.81 to 0.95)(0.83 to 0.97)(0.77 to 0.89)(0.79 to 0.91)(0.77 to 0.89)
History of myopathy0.970.950.930.990.971.000.940.96
(0.89 to 1.05)(0.87 to 1.04)(0.86 to 1.01)(0.91 to 1.07)(0.90 to 1.05)(0.73 to 1.08)(0.87 to 1.01)(0.89 to 1.03)
History of liver injury1.29* 1.190.961.041.101.15*0.951.04
(1.12 to 1.49)(1.02 to 1.37)(0.84 to 1.11)(0.91 to 1.20)(0.95 to 1.27)(1.00 to 1.31)(0.84 to 1.07)(0.92 to 1.17
  • *Indicates significant difference in prescription rate between patient with certain medical history and those without; p value <0.05.

  • †OR was calculated as the odds of being prescribed high-intensity or moderate-intensity statins for those with certain disease history compared with those without.

  • Statins were grouped into three levels of intensity according to its ability of lowering LDL-C based on 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol7 and Rosenson et al 28: (1) high-intensity statins: atorvastatin 40 mg/day, rosuvastatin  20 mg/day and simvastatin 80 mg/day; (2) moderate-intensity statins: 10  mg/day atorvastatin < 40?mg/day, 5 mg/day rosuvastatin < 20 mg/day, 20 mg/day simvastatin < 80 mg/day, pravastatin 40 mg/day, lovastatin 40 mg/day and fluvastatin 80 mg/day; and (3) low-intensity statins: atorvastatin <10 mg/day, rosuvastatin <5 mg/day, simvastatin <20 mg/day, pravastatin <40 mg/day, lovastatin <40 mg/day and fluvastatin <80 mg/ day. Individuals were defined as having a history of the following diseases if they have a diagnosis within certain years prior to the given year: coronary event (3 years), cerebrovascular event (5 years), diabetes (1 year), myopathy (3 years) and liver injury (3 years).

  • ACC/AHA, American College of Cardiology/American Heart Association; LDL-C, low-density lipoprotein cholesterol.