CIs, RSE and probability to observe at least one AEI according to expected probabilities of occurrence of AEI
| Expected population medically followed by the enrolled practices | Vaccine coverage (%) | Vaccinated subjects | Subjects with events | Expected proportion of subjects with ≥1 AEI reported (%) | Lower 95% CL (%) | Upper 95% CL (%) | Probability to observe ≥1 AEIs in the study population (%) | Associated RSE (%) |
| 50 000 | 20 | 10 000 | 2 000 | 20.00 | 19.2 | 20.8 | 100.00 | 2.0 |
| 50 000 | 20 | 10 000 | 1500 | 15.00 | 14.3 | 15.7 | 100.00 | 2.4 |
| 50 000 | 20 | 10 000 | 1 000 | 10.00 | 9.4 | 10.6 | 100.00 | 3.0 |
| 50 000 | 20 | 10 000 | 500 | 5.00 | 4.6 | 5.4 | 100.00 | 4.4 |
| 50 000 | 20 | 10 000 | 400 | 4.00 | 3.6 | 4.4 | 100.00 | 4.9 |
| 50 000 | 20 | 10 000 | 200 | 2.00 | 1.7 | 2.3 | 100.00 | 7.0 |
| 50 000 | 20 | 10 000 | 100 | 1.00 | 0.8 | 1.2 | 100.00 | 9.9 |
| 50 000 | 20 | 10 000 | 10 | 0.10 | 0.0 | 0.2 | 99.95 | 31.6 |
| 50 000 | 20 | 10 000 | 9 | 0.09 | 0.0 | 0.2 | 99.88 | 33.3 |
| 50 000 | 20 | 10 000 | 8 | 0.08 | 0.0 | 0.2 | 99.70 | 35.3 |
| 50 000 | 20 | 10 000 | 7 | 0.07 | 0.0 | 0.1 | 99.27 | 37.8 |
| 50 000 | 20 | 10 000 | 6 | 0.06 | 0.0 | 0.1 | 98.27 | 40.8 |
| 50 000 | 20 | 10 000 | 5 | 0.05 | 0.0 | 0.1 | 95.96 | 44.7 |
| 50 000 | 20 | 10 000 | 4 | 0.04 | 0.0 | 0.1 | 90.85 | 50.0 |
| 50 000 | 20 | 10 000 | 3 | 0.03 | 0.0 | 0.1 | 80.09 | 57.7 |
| 50 000 | 2 | 10 000 | 2 | 0.02 | 0.0 | 0.1 | 59.40 | 70.7 |
| 50 000 | 20 | 10 000 | 1 | 0.01 | 0.0 | 0.1 | 26.42 | 100.0 |
| 50 000 | 10 | 5 000 | 250 | 5.00 | 4.4 | 5.6 | 100.00 | 6.2 |
| 50 000 | 10 | 5 000 | 200 | 4.00 | 3.5 | 4.6 | 100.00 | 6.9 |
| 50 000 | 10 | 5 000 | 100 | 2.00 | 1.6 | 2.4 | 100.00 | 9.9 |
| 50 000 | 10 | 5 000 | 50 | 1.00 | 0.7 | 1.3 | 100.00 | 14.1 |
| 50 000 | 10 | 5 000 | 5 | 0.10 | 0.0 | 0.2 | 95.96 | 44.7 |
| 50 000 | 10 | 5 000 | 4.5 | 0.09 | 0.0 | 0.2 | 93.90 | 47.1 |
| 50 000 | 10 | 5 000 | 4 | 0.08 | 0.0 | 0.2 | 90.85 | 50.0 |
| 50 000 | 10 | 5 000 | 3.5 | 0.07 | 0.0 | 0.2 | 86.42 | 53.4 |
| 50 000 | 10 | 5 000 | 3 | 0.06 | 0.0 | 0.2 | 80.09 | 57.7 |
| 50 000 | 10 | 5 000 | 2.5 | 0.05 | 0.0 | 0.2 | 71.28 | 63.2 |
| 50 000 | 10 | 5 000 | 2 | 0.04 | 0.0 | 0.1 | 59.40 | 70.7 |
| 50 000 | 10 | 5 000 | 1.5 | 0.03 | 0.0 | 0.1 | 44.22 | 81.6 |
| 50 000 | 10 | 5 000 | 1 | 0.02 | 0.0 | 0.1 | 26.42 | 100.0 |
| 50 000 | 10 | 5 000 | 0.5 | 0.01 | 0.0 | 0.1 | 9.02 | 141.4 |
| 50 000 | 5 | 2 500 | 125 | 5.00 | 4.2 | 5.9 | 100.00 | 8.7 |
| 50 000 | 5 | 2 500 | 100 | 4.00 | 3.3 | 4.8 | 100.00 | 9.8 |
| 50 000 | 5 | 2 500 | 50 | 2.00 | 1.5 | 2.6 | 100.00 | 14.0 |
| 50 000 | 5 | 2 500 | 25 | 1.00 | 0.6 | 1.5 | 100.00 | 19.9 |
| 50 000 | 5 | 2 500 | 12.5 | 0.50 | 0.3 | 0.9 | 100.00 | 28.2 |
| 50 000 | 5 | 2 500 | 2.5 | 0.10 | 0.0 | 0.3 | 71.29 | 63.2 |
| 50 000 | 5 | 2 500 | 2.25 | 0.09 | 0.0 | 0.3 | 65.76 | 66.6 |
| 50 000 | 5 | 2 500 | 2 | 0.08 | 0.0 | 0.3 | 59.41 | 70.7 |
| 50 000 | 5 | 2 500 | 1.75 | 0.07 | 0.0 | 0.3 | 52.22 | 75.6 |
| 50 000 | 5 | 2 500 | 1.5 | 0.06 | 0.0 | 0.3 | 44.22 | 81.6 |
| 50 000 | 5 | 2 500 | 1.25 | 0.05 | 0.0 | 0.3 | 35.54 | 89.4 |
| 50 000 | 5 | 2 500 | 1 | 0.04 | 0.0 | 0.2 | 26.42 | 100.0 |
| 50 000 | 5 | 2 500 | 0.75 | 0.03 | 0.0 | 0.2 | 17.33 | 115.5 |
| 50 000 | 5 | 2 500 | 0.5 | 0.02 | 0.0 | 0.2 | 9.02 | 141.4 |
| 50 000 | 5 | 2 500 | 0.25 | 0.01 | 0.0 | 0.2 | 2.65 | 200.0 |
AEI, adverse event of interest; RSE, relative SE.