Summary of the range of plausible credible MIDs for improvement for PRO measures used to inform the systematic review of treatment effects
| PRO instrument/domain (score range) | Absolute MID* | Minimum | Maximum |
|---|---|---|---|
| WOMAC | |||
| Pain (0 to 100) | 12 | 2 | 30 |
| Function (0 to 100) | 13 | 3 | 34 |
| KOOS | |||
| Pain (0 to 100) | 12 | 4 | 20 |
| ADL (0 to 100) | 8 | 3 | 9 |
| EQ-5D (−0.59 to 1) | 0.15 | NR | NR |
MID estimates are presented as positive values, regardless of the direction of change.
*Median MID estimate.
ADL, activities of daily living; EQ-5D, EuroQol five dimensions Questionnaire; KOOS, Knee injury and Osteoarthritis Outcome Score; MID, minimal important difference; NR, not reported; PRO, patient-reported outcome; WOMAC, Western Ontario and McMaster University Osteoarthritis Index.