Table 2

Summary of the range of plausible credible MIDs for improvement for PRO measures used to inform the systematic review of treatment effects

PRO instrument/domain (score range)Absolute MID*MinimumMaximum
 Pain (0 to 100)12230
 Function (0 to 100)13334
 Pain (0 to 100)12420
 ADL (0 to 100)839
EQ-5D (−0.59 to 1)0.15NRNR
  • MID estimates are presented as positive values, regardless of the direction of change.

  • *Median MID estimate.

  • ADL, activities of daily living; EQ-5D, EuroQol five dimensions Questionnaire; KOOS, Knee injury and Osteoarthritis Outcome Score; MID, minimal important difference; NR, not reported; PRO, patient-reported outcome; WOMAC, Western Ontario and McMaster University Osteoarthritis Index.