Group/subgroup | Spearman ’s p | Cochrane Q test | Pooled sensitivity (95% CI) | Pooled specificity (95% CI) | Pooled positive LR (95% CI) | Pooled Negative NR (95% CI) | Area under the curve (95% CI) | |
diagnostic OR (95% CI) | p | |||||||
Overall | 0.413 | 73 (46.45 to 114.74) | 0.0000 | 0.83 (0.82 to 0.85) | 0.89 (0.88 to 0.90) | 8.81 (6.37 to 12.2) | 0.13 (0.09 to 0.2) | 0.96 (0.94 to 0.97) |
Age | ||||||||
Children | 0.397 | 61.62 (22.16 to 171.32) | 0.0335 | 0.53 (0.48 to 0.58) | 0.96 (0.94 to 0.97) | 17.93 (4.83 to 62.59) | 0.35 (0.22 to 0.58) | 0.96 (0.91 to 1.01) |
Adult | 0.732 | 85.12 (29.81 to 243.06) | 0.0000 | 0.87 (0.84 to 0.89) | 0.91 (0.88 to 0.94) | 8.13 (4.61 to 14.33) | 0.13 (0.07 to 0.22) | 0.96 (0.92 to 1.0) |
Region | ||||||||
Asian | 0.724 | 73.75 (43.38 to 125.38) | 0.0000 | 0.86 (0.84 to 0.88) | 0.9 (0.88 to 0.92) | 7.74 (5.77 to 10.39) | 0.12 (0.07 to 0.20) | 0.96 (0.94 to 0.97) |
Europe and USA | 0.645 | 73.75 (29.26 to 125.38) | 0.0000 | 0.80 (0.77 to 0.82) | 0.88 (0.86 to 0.90) | 12.05 (5.22 to 27.8) | 0.16 (0.07 to 0.38) | 0.96 (0.91 to 1.0) |
Study population | ||||||||
Patient | 0.616 | 54.29 (34.07 to 86.51) | 0.0000 | 0.84 (0.82 to 0.85) | 0.87 (0.85 to 0.89) | 7.17 (5.18 to 9.93) | 0.14 (0.09 to 0.23) | 0.94 (0.92 to 0.96) |
Healthy | 0.294 | 156.11 (41.44 to 588.04) | 0.0073 | 0.75 (0.69 to 0.80) | 0.97 (0.94 to 0.98) | 16.25 (6.94 to 38.06) | 0.13 (0.03 to 0.53) | 0.98 (0.96 to 1.0) |
Assay method | ||||||||
Immunochromatography | 0.5940 | 82.94 (41.62 to 165.29) | 0.0000 | 0.81 (0.78 to 0.83) | 0.92 (0.90 to 0.94) | 9.81 (6.28 to 15.34) | 0.14 (0.07 to 0.28) | 0.96 (0.93 to 0.98) |
ELISA | 0.7820 | 67.46 (35.58 to 127.9) | 0.0000 | 0.86 (0.84 to 0.87) | 0.87 (0.84 to 0.88) | 7.92 (5.02 to 12.5) | 0.12 (0.07 to 0.23) | 0.95 (0.93 to 0.98) |