Table 3

Group/subgroup analysis of pooled estimates with 95% CI for sensitivity, specificity, positive likelihood ratio (LR) and negative LR

Group/subgroup Spearman ’s pCochrane Q testPooled sensitivity 
(95% CI)		Pooled specificity 
(95% CI)		Pooled positive LR
(95% CI)		Pooled Negative NR
(95% CI)		Area under the curve
(95% CI)
diagnostic OR (95% CI)p
Overall0.41373
(46.45 to 114.74)		0.00000.83
(0.82 to 0.85)		0.89
(0.88 to 0.90)		8.81
(6.37 to 12.2)		0.13
(0.09 to 0.2)		0.96
(0.94 to 0.97)
Age
Children0.39761.62
(22.16 to 171.32)		0.03350.53
(0.48 to 0.58)		0.96
(0.94 to 0.97)		17.93
(4.83 to 62.59)		0.35
(0.22 to 0.58)		0.96
(0.91 to 1.01)
Adult0.73285.12
(29.81 to 243.06)		0.00000.87
(0.84 to 0.89)		0.91
(0.88 to 0.94)		8.13
(4.61 to 14.33)		0.13
(0.07 to 0.22)		0.96
(0.92 to 1.0)
Region
Asian0.72473.75
(43.38 to 125.38)		0.00000.86
(0.84 to 0.88)		0.9
(0.88 to 0.92)		7.74
(5.77 to 10.39)		0.12
(0.07 to 0.20)		0.96
(0.94 to 0.97)
Europe and USA0.64573.75
(29.26 to 125.38)		0.00000.80
(0.77 to 0.82)		0.88
(0.86 to 0.90)		12.05
(5.22 to 27.8)		0.16
(0.07 to 0.38)		0.96
(0.91 to 1.0)
Study population
Patient0.61654.29
(34.07 to 86.51)		0.00000.84
(0.82 to 0.85)		0.87
(0.85 to 0.89)		7.17
(5.18 to 9.93)		0.14
(0.09 to 0.23)		0.94
(0.92 to 0.96)
Healthy0.294156.11
(41.44 to 588.04)		0.00730.75
(0.69 to 0.80)		0.97
(0.94 to 0.98)		16.25
(6.94 to 38.06)		0.13
(0.03 to 0.53)		0.98
(0.96 to 1.0)
Assay method
Immunochromatography0.594082.94
(41.62 to 165.29)		0.00000.81
(0.78 to 0.83)		0.92
(0.90 to 0.94)		9.81
(6.28 to 15.34)		0.14
(0.07 to 0.28)		0.96
(0.93 to 0.98)
ELISA0.782067.46
(35.58 to 127.9)		0.00000.86
(0.84 to 0.87)		0.87
(0.84 to 0.88)		7.92
(5.02 to 12.5)		0.12
(0.07 to 0.23)		0.95
(0.93 to 0.98)