Associations and interactions of SEP and different categorisations of T2DM family history with T2DM, stratified by gender
| Males | Females | |||||
| n T2DM/n total | OR (95% CI) | RERI (95% CI) | n T2DM/n total | OR (95% CI) | RERI (95% CI) | |
| Parental T2DM | ||||||
| No parental T2DM | ||||||
| High SEP | 130/5835 | 1.00 (ref) | 52/7551 | 1.00 (ref) | ||
| Medium SEP | 153/6845 | 1.28 (1.01 to 1.63) | 82/9527 | 1.33 (0.94 to 1.89) | ||
| Low SEP | 188/4609 | 1.38 (1.10 to 1.74) | 191/5778 | 2.49 (1.81 to 3.42) | ||
| Parental T2DM | ||||||
| High SEP | 87/1123 | 3.15 (2.37 to 4.20) | 42/1471 | 3.23 (2.13 to 4.89) | ||
| Medium SEP | 120/1497 | 3.75 (2.89 to 4.88) | 0.32 (−0.72 to 1.37)* | 132/2,654 | 5.92 (4.27 to 8.22) | 2.38 (0.86 to 3.91)* |
| Low SEP | 177/1463 | 4.43 (3.48 to 5.63) | 0.88 (−0.15 to 1.91)† | 247/2372 | 7.93 (5.81 to 10.81) | 3.17 (1.50 to 4.84)† |
| Maternal T2DM | ||||||
| No maternal T2DM | ||||||
| High SEP | 131/5836 | 1.00 (ref) | 52/7553 | 1.00 (ref) | ||
| Medium SEP | 153/6846 | 1.27 (1.00 to 1.62) | 82/9530 | 1.33 (0.94 to 1.89) | ||
| Low SEP | 189/4612 | 1.38 (1.10 to 1.74) | 191/5780 | 2.44 (1.78 to 3.35) | ||
| Maternal T2DM | ||||||
| High SEP | 62/618 | 3.74 (2.71 to 5.17) | 24/744 | 3.20 (1.95 to 5.26) | ||
| Medium SEP | 87/843 | 4.28 (3.20 to 5.72) | 0.28 (−1.18 to 1.74)* | 90/1519 | 6.55 (4.61 to 9.30) | 3.00 (0.98 to 5.02)* |
| Low SEP | 122/922 | 4.39 (3.37 to 5.72) | 0.26 (−1.07 to 1.59)† | 180/1545 | 8.36 (6.05 to 11.55) | 3.61 (1.55 to 5.68)† |
| Paternal T2DM | ||||||
| No paternal T2DM | ||||||
| High SEP | 130/5835 | 1.00 (ref) | 52/7555 | 1.00 (ref) | ||
| Medium SEP | 153/6849 | 1.27 (1.00 to 1.61) | 82/9528 | 1.32 (0.93 to 1.88) | ||
| Low SEP | 188/4614 | 1.39 (1.10 to 1.75) | 191/5782 | 2.53 (1.84 to 3.48) | ||
| Paternal T2DM | ||||||
| High SEP | 40/589 | 3.11 (2.14 to 4.52) | 24/836 | 3.56 (2.17 to 5.83) | ||
| Medium SEP | 46/746 | 3.31 (2.32 to 4.72) | −0.06 (−1.58 to 1.45)* | 70/1370 | 6.64 (4.60 to 9.59) | 2.77 (0.49 to 5.05)* |
| Low SEP | 74/656 | 4.86 (3.57 to 6.60) | 1.36 (−0.27 to 2.99)† | 104/1058 | 8.35 (5.90 to 11.82) | 3.28 (0.88 to 5.68)† |
ORs are adjusted for age and age-squared.
*RERI T2DM for medium SEP.
†RERI T2DM for low SEP.
RERI, relative excess risk due to interaction; SEP, socioeconomic position; T2DM, type 2 diabetes mellitus.