Comparison of HRs obtained applying two analytic models (standard analysis vs GM) by settings
Chronic kidney disease setting | Oncology setting | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Standard analysis | GM analysis | Standard analysis | GM analysis | ||||||||||
Biosimilars vs epoetin α originator | Biosimilars vs epoetin α originator | Biosimilars vs epoetin α originator | Biosimilars vs epoetin α originator | ||||||||||
HR_adj | LCI95% | UCI95% | HR_GM | LCI95% | UCI95% | HR_adj | LCI95% | UCI95% | HR_GM | LCI95% | UCI95% | ||
Composite outcome | 1.02 | 0.78 | 1.33 | 0.85 | 0.60 | 1.20 | Composite outcome | 0.91 | 0.79 | 1.06 | 0.85 | 0.71 | 1.01 |
All-cause mortality | 0.92 | 0.67 | 1.28 | 0.70 | 0.47 | 1.06 | All-cause mortality | 0.82 | 0.70 | 0.97 | 0.76 | 0.62 | 0.93 |
Blood transfusion | 0.95 | 0.54 | 1.69 | 1.11 | 0.50 | 2.48 | Blood transfusion | 1.06 | 0.82 | 1.35 | 1.10 | 0.80 | 1.51 |
MACE | 0.92 | 0.49 | 1.70 | 0.95 | 0.41 | 2.19 | MACE | 0.84 | 0.48 | 1.47 | 0.90 | 0.44 | 1.82 |
Blood dyscrasia | 1.19 | 0.74 | 1.92 | 1.19 | 0.61 | 2.35 | Blood dyscrasia | 0.86 | 0.66 | 1.14 | 0.83 | 0.59 | 1.16 |
Biosimilars vs other originators | Biosimilars vs other originators | Biosimilars vs other originators | Biosimilars vs other originators | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HR_adj | LCI95% | UCI95% | HR_GM | LCI95% | UCI95% | HR_adj | LCI95% | UCI95% | HR_GM | LCI95% | UCI95% | ||
Composite outcome | 1.09 | 0.85 | 1.41 | 1.25 | 0.86 | 1.82 | Composite outcome | 1.01 | 0.88 | 1.16 | 0.96 | 0.80 | 1.15 |
All-cause mortality | 1.00 | 0.73 | 1.38 | 1.19 | 0.75 | 1.88 | All-cause mortality | 1.01 | 0.86 | 1.18 | 0.95 | 0.77 | 1,17 |
Blood transfusion | 0.99 | 0.57 | 1.71 | 0.81 | 0.39 | 1.68 | Blood transfusion | 0.98 | 0.77 | 1.23 | 0.96 | 0.71 | 1,31 |
MACE | 1.08 | 0.60 | 1.97 | 1.65 | 0.64 | 4.26 | MACE | 0.79 | 0.46 | 1.35 | 0.71 | 0.37 | 1,38 |
Blood dyscrasia | 1.26 | 0.80 | 1.99 | 1.13 | 0.59 | 2.18 | Blood dyscrasia | 0.86 | 0.66 | 1.12 | 0.82 | 0.59 | 1,14 |
adj, adjusted; GM, genetic matched; LCI, lower CI value; MACE,major cardiovascular events; UCI, upper CI value.