Pharmacokinetic parameters collected in the VVZ-149 protocol
| Cmax | Maximum plasma concentration over the time span specified |
| Cmax,ss | Maximum plasma concentration at steady state |
| Ctrough,ss | Plasma concentration at a dosing interval after the treatment at steady state (trough concentration at steady state) |
| Cav,ss | Average plasma concentration during a dosing interval at steady state, calculated as AUCτ,ss/τt |
| Clast | Area under the plasma concentration vs time curve, from time 0 to the last measurable concentration, calculated by the linear/log trapezoidal method |
| AUCinf | The area under the plasma concentration vs time curve from time 0 to infinity. AUCinf is calculated as the sum of AUClast plus the ratio of the last measurable plasma concentration to the elimination rate constant; AUCinf=AUClast+Clast/λZ |
| AUCτ,sst | Area under the plasma concentration vs time curve during a dosing interval (τ) at steady state, calculated by the linear/log trapezoidal method |
| CL | (VVZ-149 injection) The total body clearance after IV administration, calculated as dose/AUCinf |
| CL/F | (VVZ-368) Apparent total body clearance after IV administration, calculated as dose/AUCinf |
| MRT | Mean residence time from the time of dosing to the time of the last measurable concentration. MRT=AUMClast/AUClast |
| PTF | Peak-trough fluctuation, calculated as ((Cmax,ss—Ctrough,ss)/Cav,ss)×100 (%) |
| Tmax | Time of the maximum measured plasma concentration |
| Tmax,ss | Time of the maximum measured plasma concentration at steady state |
| t1/2 | Terminal half-life, calculated as ln(2)/λz |
| R | Accumulation ratio, AUCτ,ss/AUC0−τt |
| Vd | (VVZ-149 injection) The total volume of distribution after IV administration, calculated as dose/(AUCss×λ) |
| Metabolic ratio | Metabolic ratio, AUClast of VVZ-368/AUClast of VVZ-149 injection |
IV, intravenous.