C_{max} | Maximum plasma concentration over the time span specified |

C_{max,ss} | Maximum plasma concentration at steady state |

C_{trough,ss} | Plasma concentration at a dosing interval after the treatment at steady state (trough concentration at steady state) |

C_{av,ss} | Average plasma concentration during a dosing interval at steady state, calculated as AUC_{τ,ss}/τt |

C_{last} | Area under the plasma concentration vs time curve, from time 0 to the last measurable concentration, calculated by the linear/log trapezoidal method |

AUC_{inf} | The area under the plasma concentration vs time curve from time 0 to infinity. AUC_{inf} is calculated as the sum of AUC_{last} plus the ratio of the last measurable plasma concentration to the elimination rate constant; AUC_{inf}=AUC_{last}+C_{last}/λZ |

AUC_{τ,ss}t | Area under the plasma concentration vs time curve during a dosing interval (τ) at steady state, calculated by the linear/log trapezoidal method |

CL | (VVZ-149 injection) The total body clearance after IV administration, calculated as dose/AUC_{inf} |

CL/F | (VVZ-368) Apparent total body clearance after IV administration, calculated as dose/AUCinf |

MRT | Mean residence time from the time of dosing to the time of the last measurable concentration. MRT=AUMC_{last}/AUC_{last} |

PTF | Peak-trough fluctuation, calculated as ((C_{max,ss—}C_{trough,ss})/C_{av,ss})×100 (%) |

T_{max} | Time of the maximum measured plasma concentration |

T_{max,ss} | Time of the maximum measured plasma concentration at steady state |

t_{1/2} | Terminal half-life, calculated as ln(2)/λz |

R | Accumulation ratio, AUC_{τ,ss}/AUC_{0−τ}t |

Vd | (VVZ-149 injection) The total volume of distribution after IV administration, calculated as dose/(AUC_{ss}×λ) |

Metabolic ratio | Metabolic ratio, AUC_{last} of VVZ-368/AUC_{last} of VVZ-149 injection |

IV, intravenous.