Table 2

Examples of SHARE involvement in recruitment to different types of study challenge

Study	Challenge	Detail	Number approached	Number delivered to researcher	Number entered into study
SPIROA The Effect of Spironolactone on Pain in Older People with Osteoarthritis	Required data from both primary and secondary care	This study sought to recruit people with osteoarthritis and knee pain who had not been on NSAIDs, ACE inhibitors or spironolactone. They required eight additional participants before a 2-week deadline	25	16	8
DIRECT DIabetes REmission Clinical Trial	Rescue before recruitment closure	This study required recently diagnosed people with diabetes within 3 weeks before study closure	12	8	2
DECIDE Decision-making and comprehension of interactive and static Summary of Findings tables.	Large-scale survey	Complex survey exploring preferences for presentation of risk which had struggled to get responses. 20% response was desired. However, the survey was only compatible with desktop operating systems and therefore was inaccessible to the large numbers of registrants who clicked through from mobile devices.	50 000	16 266 viewed full email, 9183 clicked and attempted survey	Over 2000 completed.
H. PYLORI Infection And Acid Secretory Function	Anticipated high refusal rate	Study which required 150 healthy volunteers willing to undergo endoscopy	1400	251	150
REFORM—	Finding people with multiple morbidity	Research into the Effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus	63	27	15