Table 3

Crude event rates per 10 000 therapies for 14-day and 37-day all-cause mortality and CV and arrhythmia events, by first-line antibiotic monotherapy and by indication

	14-day analysis						37-day analysis
	CV		Death		Arrhythmia		CV		Death		Arrhythmia
	Events	Crude rate	Events	Crude rate	Events	Crude rate	Events	Crude rate	Events	Crude rate	Events	Crude rate
Lower respiratory tract infection
Overall	1102	15.7	3690	43.2	1393	19.3	2071	29.6	7401	86.8	3359	49.3
Amoxicillin	686	14.2	2177	37.3	948	19.1	1326	27.5	4315	74.0	2199	44.3
Erythromycin	92	14.5	251	33.5	97	15.0	163	25.7	469	62.7	245	38.1
Clarithromycin	58	16.4	225	52.2	75	21.1	103	29.3	449	104.6	197	55.5
Co-amoxiclav	67	22.7	302	81.1	65	21.1	118	40.1	614	165.2	188	61.2
Cefalexin	71	31.5	251	86.9	48	20.2	111	49.3	471	163.3	114	48.1
Doxycycline	25	15.0	47	22.7	37	22.1	43	25.9	122	59.3	90	53.9
Oxytetracycline	16	13.9	17	12.3	16	13.3	39	33.8	49	35.5	39	32.5
Other*	87	21.8	420	81.6	107	25.4	168	42.1	912	177.3	287	55.1
Upper respiratory tract infections
Overall	350	5.0	203	2.7	555	8.3	688	9.9	591	7.9	1422	21.3
Amoxicillin	187	5.4	122	3.2	316	9.4	368	10.6	359	9.4	773	23.1
Penicillin-V	40	10.7	15	1.2	45	4.0	68	5.9	32	2.6	138	12.4
Doxycycline	33	4.9	10	1.4	54	8.4	71	10.5	33	4.6	140	21.9
Erythromycin	25	4.0	15	2.2	51	8.6	46	7.4	39	5.9	137	23.1
Co-amoxiclav	14	5.9	6	2.3	23	10.0	32	13.4	25	9.7	62	27.1
Cefalexin	12	5.7	8	3.4	25	12.1	25	10.6	27	11.4	55	23.3
Clarithromycin	10	5.3	5	2.5	12	6.8	23	11.3	17	8.4	43	24.4
Other†	29	2.5	22	5.3	29	8.0	55	14.8	59	14.2	74	20.4
Upper and lower respiratory tract infections combined
Overall	1452	10.4	3893	24.2	1948	14.0	2759	19.8	7992	49.8	4781	34.4
Amoxicillin	873	10.5	2299	23.8	87	16.3	1694	20.5	4674	48.5	2972	35.8
Erythromycin	117	9.3	266	18.8	148	11.9	209	16.7	508	35.9	382	30.9
Penicillin-V	43	3.6	22	1.8	53	4.6	73	6.1	52	4.2	148	13.0
Doxycycline	58	6.9	57	6.1	91	11.3	114	13.5	155	16.7	230	28.6
Co-amoxiclav	81	15.2	308	48.8	81	15.2	150	28.1	639	101.5	250	46.6
Clarithromycin	68	12.6	230	36.2	68	12.6	126	23.4	466	73.7	240	45.2
Cefalexin	83	19.0	259	49.4	83	19.0	136	25.4	498	95.0	169	38.1
Oxytetracycline	25	11.4	18	7.1	25	11.4	53	24.2	53	21.0	55	24.8
Other‡	104	16.2	434	55.3	104	16.2	204	31.9	947	120.7	335	51.3

*Forty-six antibiotics (10 most frequently used: penicillin-V, flucloxacillin, cefradine, azithromycin, tetracycline, ampicillin, cefadroxil, ofloxacin, levofloxacin, nitrofurantoin).
†Thirty-one antibiotics (10 most frequently used: ciprofloxacin, flucloxacillin, tetracycline, cefradine, cefadroxil, azithromycin, metronidazole, nitrofurantoin, ampicillin, co-fluampicil).
‡Forty-nine antibiotics (10 most frequently used: trimethroprim, cefaclor, ciprofloxacin, flucloxacillin, cefradine, tetracycline, azithromycin, ampicillin, cefadroxil, nitrofurantoin, metronidazole).
CV, cardiovascular.