Risk factors for probable hospital-acquired suspected ADRs in 87 of 762 inpatients, Uganda, 2014
| Probable ADR, n (%) | Crude analysis | Adjusted analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristics | Yes | No | OR | 95% CI for OR | p Value | β-adj | OR | 95% CI for OR | p Value |
| Gender | |||||||||
| Male | 22 (10) | 206 (90) | 1.0 | 1.00 | |||||
| Female | 65 (12) | 469 (88) | 1.3 | 0.78 to 2.16 | 0.317 | 0.291 | 1.34 | 0.79 to 2.25 | 0.273 |
| Age: mean (SD) | 34.6 (15.8) | 34.8 (14.7) | 0.97 | 0.98 to 1.01 | 0.888 | −0.010 | 1.01 | 0.97 to 1.01 | 0.269 |
| Number of conventional medicines | |||||||||
| Five or less | 16 (7) | 228 (93) | 1.0 | 1.00 | |||||
| Six or more | 71 (14) | 447 (86) | 2.3 | 1.29 to 3.98 | 0.005 | 0.838 | 2.31 | 1.29 to 4.15 | 0.005 |
| Use of herbal medicines in the 4 weeks prior hospitalisation | |||||||||
| No | 52 (9) | 503 (91) | 1.0 | 1.00 | |||||
| Yes | 35 (17) | 172 (83) | 2.0 | 1.24 to 3.12 | 0.004 | 0.673 | 1.96 | 1.22 to 3.13 | 0.005 |
| HIV-positive | |||||||||
| No or unknown | 59 (11) | 471 (89) | 1.0 | 1.00 | |||||
| Yes | 28 (12) | 204 (88) | 1.1 | 0.68 to 1.77 | 0.708 | 0.317 | 0.73 | 0.41 to 1.31 | 0.288 |
| Charlson's comorbidity index | |||||||||
| Two or fewer | 60 (11) | 507 (89) | 1.0 | 1.00 | |||||
| Three or more | 27 (14) | 168 (86) | 1.4 | 0.83 to 2.21 | 0.218 | 0.505 | 1.66 | 0.88 to 3.13 | 0.119 |
| Intercept | −2.807 | 0.06 | 0.03 to 0.14 | ||||||
Except for gender (male coded 1 and female coded 2), indicator variables were coded 0 for baseline, 1 otherwise; regression χ2=20.36 on 6 df (p∼0.0024); β-adj=adjusted regression coefficient.
ADR, adverse drug reaction.