Screening for CMV | Re-examination of CMV | First MRI examination | Second MRI examination | AABR | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Pt no | Age (days) | Copies/mL | Age (weeks) | Copies/mL | Age (weeks) | Findings | Age (months) | Findings | Right | Left | Outcome* |
1† | 1 | 1.9×108 | 5 | 1.9×108 | 6 | WMA, periventricular cysts | 27 | WMA, ventriculomegaly | R (−90 dB)‡ | P | SNHL, PDD, speech delay |
2† | 4 | 8.0×106 | 2 | 7.2×107 | 12 | WMA | 18 | WMA | R (−100 dB) | R (−70 dB) | SNHL, PDD, speech delay, calcification§ |
3† | 0 | 3.2×108 | 24 | 2.5×106 | 78 | WMA, ventriculomegaly, hippocampal dysplasia | Declined | R (−80 dB) | R (no response) | SNHL, PDD, speech delay | |
4† | 4 | 4.8×106 | 3 | 7.1×107 | 4 | WMA | 18 | WMA | R (−100 dB) | P | SNHL, PDD, speech delay |
5† | 1 | 1.5×107 | 32 | 2.1×107 | 6 | WMA | 9 | WMA, cerebral parenchymal atrophy | ND | ND | Late-onset hearing loss |
6 | 1 | 4.1×106 | 10 | 1.8×106 | 12 | Polymicrogyria, ventriculomegaly, WMA | 18 | Polymicrogyria, WMA, ventriculomegaly, periventricular cysts | P | P | Left hemiparesis, PDD |
7 | 2 | 1.0×107 | 5 | 1.8×108 | 8 | WMA | 18 | WMA | P | P | Microcephaly, speech delay |
8 | 4 | 5.2×105 | 9 | 2.0×106 | 7 | WMA, vestibulo-semicircular canal dysplasia | Not yet done¶ | P | P | ||
9 | 1 | 8.0×106 | 41 | 2.5×107 | 40 | WMA, infarct | 18 | WMA | P | P | |
10 | 4 | 2.1×106 | 6 | 8.6×107 | 7 | WMA, coagulation, necrosis around posterior horn of both lateral ventricles | 18 | WMA | P | P | |
11 | 1 | 2.5×106 | 5 | 5.3×107 | 5 | WMA | 18 | WMA, ventriculomegaly | P | P | |
12 | 1 | 3.1×107 | 10 | 3.1×107 | 12 | WMA | 18 | WMA | P | P | |
13 | 2 | 2.0×105 | 6 | 5.0×104 | 11 | WMA | 18 | WMA | P | P | |
14 | 4 | 3.3×108 | 6 | 4.9×107 | 6 | WMA | 18 | WMA | P | P | |
15 | 4 | 5.4×108 | 8 | 4.3×108 | 6 | WMA | 18 | WMA | P | P | |
16 | 4 | 1.3×105 | 8 | 2.2×106 | 11 | WMA | 18 | WMA | P | P | |
17 | 4 | 1.0×107 | 5 | 3.8×106 | 7 | WMA | 18 | WMA | P | P | |
18 | 3 | 1.3×107 | 4 | 2.3×106 | 12 | WMA | 19 | WMA | P | P | |
19 | 4 | 5.7×106 | 3 | 4.5×106 | 3 | WMA | 9 | WMA | P | P | |
20 | 4 | 2.3×105 | No urine collection | 8 | WMA | 12 | WMA | P | P | ||
21 | 1 | 4.8×107 | 5 | 9.4×105 | 8 | WMA | 11 | WMA | P | P | |
22 | 4 | 4.8×107 | 5 | 1.1×107 | 6 | WMA | 17 | WMA | ND | ND | |
23 | 4 | 1.4×105 | 10 | 1.4×107 | 12 | WMA | 18 | WMA | P | P | |
24 | 4 | 7.3×104 | 5 | 7.6×104 | 5 | WMA | 17 | WMA | P | P | |
25 | 4 | 9.2×104 | 6 | 1.1×106 | 4 | WMA | 17 | WMA | P | P | |
26 | 4 | 7.9×105 | 8 | 1.5×107 | 9 | WMA | 18 | WMA | P | P | |
27 | 2 | 3.5×104 | 6 | 3.5×105 | 10 | WMA | 18 | Normal | P | P | |
28 | 4 | 3.6×105 | 8 | 3.4×106 | 11 | WMA | 17 | Normal | P | P | |
29 | 1 | 4.0×107 | 9 | 1.8×106 | 13 | WMA | 17 | Normal | P | P | |
30 | 4 | 9.6×104 | 5 | 1.1×107 | 8 | WMA | 19 | Normal | P | P | |
31 | 1 | 1.1×106 | 9 | 2.1×105 | 11 | WMA | 18 | Normal | ND | ND | |
32 | 1 | 1.6×108 | 4 | 6.9×107 | 5 | WMA | Declined | P | P | ||
33 | 4 | 1.9×105 | 9 | 6.6×105 | 14 | WMA | Declined | P | P | ||
34 | 4 | 5.1×106 | 15 | 2.9×105 | 7 | WMA | Not yet done | P | P | ||
35 | 4 | 3.7×105 | 8 | 3.4×105 | 8 | WMA | Declined | P | P | ||
36 | 4 | 1.1×104 | 6 | 4.8×105 | 8 | WMA | Not yet done | P | P | ||
37 | 1 | 3.9×104 | 6 | 1.3×105 | 5 | WMA | Not yet done | ND | ND | ||
38 | 1 | 1.5×107 | No urine collection | 7 | WMA | Not yet done | P | P | |||
39 | 4 | 6.9×107 | 15 | 9.8×106 | 14 | Normal | 20 | WMA | P | P | |
40 | 1 | 1.1×109 | 16 | 2.0×107 | 18 | Normal | 18 | WMA | P | P | |
41 | 1 | 3.5×107 | 10 | 6.2×106 | 13 | Normal | 17 | WMA | P | P | |
42 | 4 | 6.7×105 | 8 | 6.2×105 | 10 | Normal | 24 | WMA | P | P | |
43 | 4 | 3.6×105 | 9 | 4.7×106 | 11 | Normal | 22 | WMA | P | P | Cavum vergae |
44 | 2 | 1.4×107 | 8 | 4.4×105 | 9 | Normal | 18 | WMA | ND | ND | |
45 | 4 | 6.1×104 | 8 | 6.1×104 | 7 | Normal | 16 | Normal | P | P | |
46 | 4 | 3.8×104 | 11 | 2.2×106 | 16 | Normal | 18 | Normal | P | P | |
47 | 4 | 1.2×106 | 12 | 1.6×107 | 12 | Normal | 17 | Normal | P | P | |
48 | 1 | 4.5×103 | 4 | 3.1×105 | 4 | Normal | Declined | P | P | ||
49 | 1 | 6.4×106 | 14 | 4.1×105 | 15 | Normal | Declined | P | P | ||
50 | 4 | 7.4×105 | 13 | 2.2×106 | 28 | Normal | Declined | P | P | ||
51 | 4 | 6.1×104 | 3 | 1.2×105 | 5 | Normal | Declined | P | P | ||
52 | 4 | 1.1×106 | 13 | 6.0×106 | 12 | Normal | Not yet done | P | P | ||
53 | 4 | 9.3×105 | 7 | 3.9×106 | 8 | Normal | Not yet done | P | P | ||
54 | 1 | 1.1×104 | Not examined** | Not examined | Not examined | P | P | ||||
55 | 1 | 3.1×106 | Not examined | Not examined | Not examined | P | P | ||||
56 | 3 | 2.4×106 | Not examined | Not examined | Not examined | P | P | ||||
57 | 4 | 7.7×106 | Not examined | Not examined | Not examined | P | P | ||||
58 | 4 | 2.4×103 | Not examined | Not examined | Not examined | P | P | ||||
59 | 1 | 1.0×104 | Not examined | Not examined | Not examined | ND | ND | ||||
60 | 2 | 1.1×108 | Not examined | Not examined | Not examined | ND | ND |
Microcephaly was noted in one newborn with modified HC z score of −2.95.
*No data means the patient had shown no apparent clinical manifestations until documentation of this paper.
†The oral antiviral drug valganciclovir was administered to patients 1–5 with SNHL for 5–6 months. Patient 5 presented with late-onset hearing loss and was then treated with valganciclovir.
‡Figures in parentheses indicate hearing loss measured in decibel (dB).
§Calcification was confirmed with CT scan.
¶Not yet done means that the second MRI examination is scheduled but had not yet been done until documentation of this paper.
**Not examined means no visit or examinations.
AABR, automatic auditory brainstem response; HC, nead circumference; nt, not tested; P, pass; PDD, psychomotor developmental delays; Pt no, patient number; R, refer; SNHL, sensorineural hearing loss; WMA, white matter abnormality.