Table 2

Associations of reallocating 30 min of prolonged and short sitting/lying for standing or stepping with measures of glucose regulation and insulin sensitivity

nProlonged ST to short STp ValueProlonged ST to standingp ValueProlonged ST to steppingp ValueShort ST to standingp ValueShort ST to steppingp Value
Model 1 (coefficient (95% CI)
 Fasting glucose4351.00 (0.99 to 1.00)0.1781.00 (0.99 to 1.01)0.3950.98 (0.97 to 0.99)0.0461.00 (0.99 to 1.01)0.7810.99 (0.98 to 1.00)0.082
 2-hour glucose4220.99 (0.97 to 1.01)0.2351.00 (0.98 to 1.01)0.4600.94 (0.92 to 0.97)0.0011.00 (0.99 to 1.00)0.4290.95 (0.92 to 0.97)<0.001
 Fasting insulin3070.96 (0.93 to 0.99)0.0100.95 (0.92 to 0.98)0.0010.89 (0.84 to 0.95)0.0010.98 (0.95 to 1.01)0.2040.93 (0.88 to 0.98)0.006
 2-hour insulin2660.97 (0.92 to 1.02)0.1470.94 (0.90 to 0.99)0.0290.85 (0.78 to 0.92)0.0020.98 (0.94 to 1.02)0.2580.87 (0.81 to 0.93)0.003
 HOMA-IS3071.04 (1.01 to 1.07)0.0121.06 (1.02 to 1.10)0.0021.15 (1.06 to 1.26)0.0011.02 (0.99 to 1.05)0.2841.10 (1.03 to 1.17)0.004
 Matsuda-ISI2641.03 (0.99 to 1.07)0.1001.06 (1.01 to 1.11)0.0181.22 (1.09 to 1.35)<0.0011.02 (0.99 to 1.06)0.2391.17 (1.07 to 1.27)<0.001
Model 2 (coefficient (95% CI)
 Fasting glucose4351.00 (0.99 to 1.01)0.1881.00 (0.99 to 1.01)0.6110.99 (0.98 to 1.00)0.1591.00 (0.99 to 1.01)0.8661.00 (0.98 to 1.01)0.261
 2-hour glucose4220.99 (0.97 to 1.01)0.2361.00 (0.98 to 1.02)0.6020.95 (0.92 to 0.98)0.0021.00 (0.99 to 1.00)0.4170.95 (0.93 to 0.98)0.001
 Fasting insulin3070.96 (0.94 to 0.98)0.0130.96 (0.93 to 0.99)0.0280.93 (0.88 to 0.98)0.0070.99 (0.96 to 1.02)0.5320.96 (0.92 to 1.00)0.173
 2-hour insulin2660.97 (0.92 to 1.02)0.1580.95 (0.91 to 1.00)0.0520.87 (0.80 to 0.94)0.0110.99 (0.95 to 1.03)0.4410.90 (0.83 to 0.98)0.021
 HOMA-IS3071.04 (1.01 to 1.07)0.0161.04 (1.01 to 1.07)0.0121.09 (1.01 to 1.17)0.0241.00 (0.97 to 1.03)0.6801.05 (0.99 to 1.11)0.143
 Matsuda-ISI2641.03 (0.98 to 1.08)0.1161.05 (1.01 to 1.09)0.0421.16 (1.05 to 1.28)0.0041.01 (0.96 to 1.05)0.5151.12 (1.03 to 1.22)0.008
  • Model 1 was adjusted for age, sex, smoking status, family history of T2DM, ethnicity, β-blockers, lipid-lowering medication and activPAL waking wear time. Model 2 was additionally adjusted for waist circumference.

  • Bolded values indicate statistically significant (p<0.05) associations.

  • ST, sitting time.