Table 1

Standard care and additional to standard care procedures

ProcedureTimingDose, frequency and/or duration
Standard care
 Appendicectomy laparoscopic or openDuring admissionOnce only
 Preoperative antibioticDuring admissionOnce only
 Postoperative antibioticDuring admission and/or after dischargeAs clinically indicated
 Follow-up visit4 to 6 weeks after dischargeOnce only
Additional to standard care
 Intravenous piperacillin with tazobactamDuring admission100 mg/kg/dose every 8 hours for at least 24 hours up to 48 hours
 Appendicectomy laparoscopic or openDuring admission when patient failed to respond to antibiotic therapyNone, or once only
 Oral amoxicillin plus clavulanic acidOn discharge22.5 mg/kg/dose twice per day to complete a total 7-day course of antibiotics
 Oral ciprofloxacin and metronidazoleOn discharge for patient allergic to augmentin15 mg/kg/dose two times per day, and 10 mg/kg/dose two times per day, respectively, to complete a total 7-day course of antibiotics
 Telephone interview1, 2 weeks, 3, 6 and 12 months after discharge5–10 min each interview. 5 times in total