Incidence rates and HRs of obstructive sleep apnoea in study population by study cohort and covariates
| Variable | Event | PY | Rate† | Relative HR (95% CI) | Adjusted HR‡ (95% CI) |
|---|---|---|---|---|---|
| RA | |||||
| No | 39 | 225 165 | 1.73 | 1.00 | 1.00 |
| Yes | 67 | 220 536 | 3.04 | 1.75 (1.18 to 2.60)*** | 1.75 (1.18 to 2.60)*** |
| Age, year | |||||
| 20–49 | 42 | 186 857 | 2.25 | 1.00 | 1.99 (1.09 to 3.65)* |
| 50–64 | 44 | 170 349 | 2.58 | 1.15 (0.75 to 1.75) | 1.64 (0.95 to 2.83) |
| ≥65 | 20 | 88 493 | 2.26 | 1.00 (0.59 to 1.71) | 1.00 |
| Sex | |||||
| Female | 53 | 353 496 | 1.50 | 1.00 | 1.00 |
| Male | 53 | 92 205 | 5.75 | 3.84 (2.62 to 5.62)*** | 4.19 (2.85 to 6.15)*** |
| Comorbidity | |||||
| Hypertension | |||||
| No | 63 | 314 159 | 2.01 | 1.00 | 1.00 |
| Yes | 43 | 131 542 | 3.27 | 1.63 (1.11 to 2.41)* | 1.12 (0.69 to 1.80) |
| Diabetes | |||||
| No | 95 | 414 708 | 2.29 | 1.00 | 1.00 |
| Yes | 11 | 30 993 | 3.55 | 1.55 (0.83 to 2.90) | – |
| Hyperlipidaemia | |||||
| No | 70 | 364 848 | 1.92 | 1.00 | 1.00 |
| Yes | 36 | 80 853 | 4.45 | 2.33 (1.56 to 3.48)*** | 1.88 (1.19 to 2.96)** |
| IHD | |||||
| No | 74 | 383 569 | 1.93 | 1.00 | 1.00 |
| Yes | 32 | 62 131 | 5.15 | 2.68 (1.77 to 4.07)*** | 2.41 (1.47 to 3.95)*** |
| Dysrhythmia | |||||
| No | 96 | 420 524 | 2.28 | 1.00 | 1.00 |
| Yes | 10 | 25 176 | 3.97 | 1.74 (0.91 to 3.35) | – |
| CHF | |||||
| No | 102 | 436 263 | 2.34 | 1.00 | 1.00 |
| Yes | 4 | 9438 | 4.24 | 1.81 (0.67 to 4.93) | – |
| Stroke | |||||
| No | 103 | 435 955 | 2.36 | 1.00 | 1.00 |
| Yes | 3 | 9746 | 3.08 | 1.30 (0.41 to 4.11) | – |
| CKD | |||||
| No | 103 | 440 392 | 2.34 | 1.00 | 1.00 |
| Yes | 3 | 5309 | 5.65 | 2.41 (0.76 to 7.59) | – |
| Asthma/COPD | |||||
| No | 92 | 408 410 | 2.25 | 1.00 | 1.00 |
| Yes | 14 | 37 291 | 3.75 | 1.67 (0.95 to 2.94) | – |
| Obesity | |||||
| No | 100 | 441 155 | 2.27 | 1.00 | 1.00 |
| Yes | 6 | 4546 | 13.2 | 5.86 (2.57 to 13.4)*** | 5.22 (2.24 to 12.2)*** |
*p<0.05, ** p<0.01, *** p<0.001.
†Incidence rate per 10 000 person-years.
‡Multivariable analysis including sex, age and comorbidities of hypertension, diabetes, hyperlipidemia, IHD, dysrhythmia, CHF, stroke, CKD, asthma/COPD and obesity.
CHF, congestive heart failure; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; IHD, ischemic heart disease; PY, person-years; RA, rheumatoid arthritis.