Table 2

Mortality, ages 40–69, by number of births and number of perinatal losses, in 652 320 mothers

Mothers stratified by number of births, and then number of lossesCardiovascular mortalityNon-cardiovascular mortality
N (per 1000)Deaths (per 1000)(HR 95% CI)*NDeaths (per 1000)(HR 95% CI)*
One birth (18%)
 Total115 603550 (4.8)117 1233588 (31) 
 No loss114 595 (991)531 (4.6)1.0 (ref)116 0913513 (30)1.0 (ref)
 One loss1008 (9)19 (19)2.5 (1.6 to 4.0)103675 (72)1.7 (1.4 to 2.2)
Two births (49%)
 Total315 517797 (2.5)318 5136789 (21) 
 No loss312 694 (991)775 (2.5)1.0 (ref)315 6296646 (21)1.0 (ref)
 One loss2730 (9)20 (7.0)2.1 (1.4 to 3.3)2788135 (48)1.7 (1.5 to 2.1)
 Two losses93 (0)2 (22)5.0 (1.2 to 20)968 (82)2.4 (1.2 to 4.9)
Three births (26%)
 Total166 266404 (2.4)167 6093091 (18) 
 No loss158 471 (953)358 (2.3)1.0 (ref)159 7602935 (18)1.0 (ref)
 One loss7542 (45)41 (5.4)1.9 (1.3 to 2.6)7593144 (19)1.4 (1.2 to 1.6)
 Two or more losses253 (1.5)5 (20)5.7 (2.3 to 14)25612 (47)1.7 (0.97 to 3.0)
Four births (6%)
 Total37 947107 (2.8)38 299810 (21) 
 No loss33 064 (871)88 (2.7)1.0 (ref)33 361681 (20)1.0 (ref)
 One loss4443 (117)16 (3.6)1.3 (0.75 to 2.2)4487104 (23)1.1 (0.88 to 1.3)
 Two or more losses440 (12)3 (7)2.0 (0.63 to 6.4)45125 (55)2.0 (1.4 to 3.0)
Five or more births (2%)
 Total971137 (3.8)9808212 (22) 
 No loss7888 (812)28 (3.5)1.0 (ref)7943166 (21)1.0 (ref)
 One loss1519 (156)8 (5.3)1.4 (0.65 to 3.1)153037 (24)1.1 (0.79 to 1.6)
 Two or more losses304 (31)1 (3.3)0.81 (0.11 to 5.9)3359 (27)1.2 (0.64 to 2.4)
  • *HR with 95% CI, adjusted for the mothers' birth year and age at first birth.