Number (%) | |||
---|---|---|---|
Cardiovascular diseases N=601 | Oncology N=251 | Mental Health N=594 | |
Overall status* | |||
Not yet recruiting | 39 (6.5) | 7 (2.8) | 16 (2.7) |
Recruiting | 129 (21.5) | 84 (33.5) | 106 (17.8) |
Completed | 331 (55.1) | 106 (42.2) | 404 (68) |
Suspended | 2 (0.3) | 2 (0.8) | 0 (0.0) |
Terminated | 39 (6.5) | 13 (5.2) | 30 (5.1) |
Withdrawn | 16 (2.7) | 5 (2.0) | 10 (1.7) |
Active, not recruiting | 42 (7) | 28 (11.2) | 26 (4.4) |
Enrolling by invitation | 3 (0.5) | 6 (2.4) | 2 (0.3) |
Enrolment, median (IQR) | 163.0 (70.0–400.0) | 100.0 (48.0–200.0) | 88.0 (40.0–226.0) |
1–299 | 391 (65.1) | 205 (81.7) | 475 (80) |
300–599 | 83 (13.8) | 24 (9.6) | 80 (13.5) |
600–2999 | 90 (15) | 14 (5.6) | 27 (4.5) |
≥3000 | 17 (2.8) | 2 (0.8) | 5 (0.8) |
Missing | 20 (3.3) | 6 (2.4) | 7 (1.2) |
Intervention model | |||
Crossover assignment | 23 (3.8) | 5 (2.0) | 35 (5.9) |
Single group assignment | 10 (1.7) | 4 (1.6) | 8 (1.3) |
Parallel assignment | 451 (75.0) | 104 (41.4) | 359 (60.4) |
Factorial assignment | 115 (19.1) | 138 (55.0) | 191 (32.2) |
Missing | 2 (0.3) | 0 (0.0) | 1 (0.2) |
Allocation | |||
Randomised | 469 (78.0) | 101 (40.2) | 390 (65.7) |
Non-randomised | 108 (18.0) | 139 (55.4) | 190 (32.0) |
Missing | 4 (0.7) | 4 (1.6) | 3 (0.5) |
Uncertain | 20 (3.3) | 7 (2.8) | 11 (1.9) |
Blinding | |||
Double-Blind | 213 (35.8) | 33 (13.2) | 292 (49.2) |
Single blind | 51 (8.5) | 7 (2.8) | 31 (5.2) |
Open label | 322 (53.6) | 207 (82.5) | 252 (42.4) |
Missing | 1 (0.2) | 0 (0) | 2 (0.3) |
Uncertain | 14 (2.3) | 4 (1.6) | 17 (2.9) |
Sex, % | |||
Women only | 8 (1.3) | 34 (13.5) | 13 (2.2) |
Men only | 9 (1.5) | 21 (8.4) | 31 (5.2) |
Both | 584 (97.2) | 196 (78.1) | 550 (92.6) |
Missing | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Included children (<18 years) | 33 (5.5) | 35 (13.9) | 112 (18.9) |
Excluded elder (>65 years) | 47 (7.8) | 24 (9.6) | 386 (65.0) |
Lead sponsor | |||
Industry | 305 (50.7) | 148 (59.0) | 360 (60.6) |
NIH | 6 (1.0) | 1 (0.4) | 53 (8.9) |
US Federal | 2 (0.3) | 0 (0.0) | 3 (0.5) |
Hospitals and similar institutions | 119 (19.8) | 39 (15.5) | 55 (9.3) |
Universities and similar institutions | 108 (18.0) | 32 (12.7) | 80 (13.5) |
Other | 61 (10.1) | 31 (12.4) | 43 (7.2) |
Region† | |||
Africa | 20 (3.3) | 13 (5.2) | 13 (2.2) |
Asia and Pacific | 210 (34.9) | 106 (42.2) | 137 (23.1) |
Central and South America | 26 (4.3) | 14 (5.6) | 41 (6.9) |
Europe | 167 (27.8) | 82 (32.7) | 76 (12.8) |
Middle East | 24 (4.0) | 19 (7.6) | 25 (4.2) |
North America | 172 (28.6) | 59 (23.5) | 314 (52.9) |
Missing | 57 (9.5) | 26 (10.4) | 56 (9.4) |
Study registration | |||
Start before submission | 27 (4.5) | 10 (4.0) | 12 (2.0) |
Start after submission | 574 (95.5) | 241 (96.0) | 582 (98.0) |
*‘Recruiting’, ‘Not yet recruiting’ mean studies that are currently recruiting participants, or will be recruiting participants in the future, respectively. ‘Active, not recruiting’, ‘Completed’ mean studies that are no longer recruiting participants because they have enough participants already or they are completed, respectively. ‘Terminated’, ‘Suspended’, ‘Withdrawn’ mean they studies that have been stopped for some reasons.
†Percentages may not sum to 100%, as categories are not mutually exclusive.