Table 2

Schedule of enrolment, interventions and assessments

	Both groups	Usual care group					IPC group
Study procedures	Consent/baseline	Postrandomisation	Days 2–5	Day 7	Day 14	Day 30, 60, 90	Postrandomisation	Day 4	Day 7	Day 14	Day 30, 60, 90	Ongoing (between follow-up)
Sign consent	X
Demographics/medical history/blood pressure	X
Randomisation	X
Local anaesthesia		X					X
Ultrasound-guided IPC or chest drain insertion		X					X
Pleural manometry		X					X
Daily observations (HR, respiratory rate, oxygen requirement, BP, chest drain assessment) drain in situ			X
Inpatient drainage			X
Community drainages												X
Drainage booklet							X					X
Pleurodesis			X					X
Drain removal			X							X
AE data collection		X	X	X	X	X	X	X	X	X	X	X
Chest X-ray	X	X	X	X	X	X	X	X*	X	X	X	X
Thoracic ultrasound	X			X	X	X		X	X	X	X
VAS assessment (pain and breathlessness)	X			X	X	X			X	X	X
EORTC QLQ -C30	X			X	X	X			X	X	X
MRC Dyspnoea Score	X			X	X	X			X	X	X
WHO performance status	X

*Optional CXR based on USS appearances.
AE, adverse events; CXR, chest X-ray; IPC, indwelling pleural catheter; MRC, Medical Research Council; USS, ultrasound scan.