Table 4

Previous studies on the association between seropositivity of HSV1 or HSV2 and BMI, obesity or overweight using data from the NHANES

Authors (reference)YearStudy populationSexAge range; mean (SD)Anthropometric measuresVirus typeHypothesis directionResultsNote
Nagelkerke et al232006NHANES 1999–2000979 Men, 1250 womenM: 34.4 (8.5), F: 33.6 (8.5)Overweight (BMI>25), obese (BMI>30)HSV2Obesity→infectionBeing obese or overweight was not associated with HSV2 antibodies.Not related in men or women
Wee et al242008NHANES 1999–20043329 Women20–59Obesity (BMI≥30)HSV2Obesity→infectionHigher BMI was not associated with HSV2 seropositivity after adjustment.Not related in women
Schooling et al172011NHANES III 1988–19945670 Men, 5836 women; 4561 men, 5013 women≥17SDs of abdominal obesity (WHR) and BMIHSV1, HSV2Infection→obesity‘Childhood’ pathogens, including HSV1 were positively associated with WHR among women but not men after adjustment.HSV1 infection was associated with abdominal obesity in women.
Karjala et al222012NHANES 2007–20081536 Men20–49Obesity (BMI≥30)HSV1Obesity→infectionHaving a BMI classified as the obese group (BMI 30–39.9) was significantly associated with HSV1 infection before and after adjustment.Obesity may increase the risk for HSV1 infection in men.
Mendy et al112013NHANES 1999–20106674 Men, 7741 women20–49; 34.3BMIHSV1, HSV2Infection→CVDBMI was significantly higher in HSV2 seropositive participants than in those seronegative for HSV or seropositive for HSV1 (unadjusted).HSV2 was associated with premature CVD but not HSV1 in adults (not stratified by sex).
  • BMI, body mass index; CVD (self-reported) cardiovascular disease; F, females; HSV, herpes simplex virus; M, males; NHANES, National Health and Nutrition Examination Survey; WHR, waist-to-hip ratio.