Clinical and virological characteristics in HCV-infected patients according to HBsAg status
| Characteristic | HBsAg positive (HBV+HCV) (n=41) | HBsAg negative (HCV) (n=956) | p Value |
|---|---|---|---|
| Male sex, n (%) | 23 (56.10) | 523 (54.70) | 0.861 |
| Median age, years (range) | 51 (28–68) | 45 (18–77) | 0.909 |
| Mode of transmission, n (%) | |||
| Transfusion | 26 (63.41) | 549 (57.43) | 0.448 |
| Intravenous drug use and other | 15 (36.59) | 407 (42.57) | |
| Alanine transaminase, IU/L (range) | 45 (13–483) | 56 (6–1301) | 0.064 |
| Aspartate transaminase, IU/L (range) | 46 (20–330) | 46 (12–587) | 0.542 |
| Total bilirubin, μmol/L (range) | 15.1 (5.3–412.9) | 15.0 (3.1–280.8) | 0.841 |
| Albumin, g/L (range) | 43.1 (26.5–51.3) | 44.4 (18.2–58.7) | 0.065 |
| Glutamine transferase, IU/L (range) | 36 (10–453) | 37 (6–712) | 0.715 |
| Total cholesterol, mmol/L (range) | 4.08 (1.89–5.45) | 4.00 (1.01–12.51) | 0.779 |
| Platelets, 109/L (range) | 140 (50–375) | 155 (11–541) | 0.700 |
| Log10 HCV RNA, IU/mL (mean±SD) | 5.80±0.89 | 5.83±1.00 | 0.904 |
| Genotypes, n (%) | 0.493 | ||
| 1 | 23 (56.10) | 559 (58.47) | |
| 1b | 22 (53.65) | 544 (56.90) | |
| 1a | 1 (2.44) | 13 (1.36) | |
| 2 | 9 (21.95) | 231 (24.16) | |
| 3 | 4 (9.75) | 87 (9.10) | |
| 6 | 5 (9.75) | 58 (6.06) | |
| Multiple genotypes* | 0 (0) | 21 (2.19) | |
*Multiple genotypes: 18 patients were mix infected with genotype 1 and 2; 1 patient was mix infected with genotype 1 and 3; 1 patient was mix infected with genotype 1 and 6; 1 patient was mix infected with genotype 1, 2 and 6.
HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; HCV, hepatitis C virus.