Cost-effectiveness results—primary and sensitivity analyses
| Mean cost, £ (95% CI) | Mean QALY (95% CI) | Probability collaborative care cost-effective (vs usual care) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Usual care | Collaborative care | Net cost | Usual care | Collaborative care | Net QALY | Net cost per QALY, £ | WTPT=£15k per QALY | WTPT=£20k per QALY | WTPT=£30k per QALY | |
| Primary | ||||||||||
| 24-month horizon | 9338 (101 to 41 379) | 10 012 (125 to 43 131) | 674 | 0.97 (0.39 to 1.77) | 1.01 (0.41 to 1.83) | 0.04 | 16 123 | 0.53 | 0.54 | 0.56 |
| Sensitivity | ||||||||||
| 12-month time horizon | 4800 (58 to 19 322) | 5359 (75 to 21 596) | 560 | 0.50 (0.22 to 0.87) | 0.53 (0.23 to 0.90) | 0.03 | 19 207 | 0.52 | 0.53 | 0.54 |
| 36-month time horizon | 13 720 (129 to 63 260) | 14 507 (160 to 65 497) | 787 | 1.43 (0.54 to 2.68) | 1.49 (0.57 to 2.76) | 0.05 | 14 660 | 0.53 | 0.56 | 0.58 |
| Excluding training costs (£131/participant) | 9338 (101 to 41 379) | 9882 (121 to 42 800) | 544 | 0.97 (0.39 to 1.77) | 1.01 (0.41 to 1.83) | 0.04 | 13 005 | 0.53 | 0.55 | 0.57 |
| Waning benefit of CC—33%/cycle | 9338 (101 to 41 379) | 9959 (123 to 43 517) | 620 | 0.97 (0.39 to 1.77) | 1.05 (0.60 to 1.60) | 0.08 | 7854 | 0.57 | 0.59 | 0.60 |
| Waning benefit of CC—25%/cycle | 9338 (101 to 41 379) | 9941 (122 to 44 344) | 602 | 0.97 (0.39 to 1.77) | 1.06 (0.63 to 1.56) | 0.09 | 6673 | 0.57 | 0.58 | 0.60 |
| Waning benefit of CC—10%/cycle | 9338 (101 to 41 379) | 9891 (119 to 45 312) | 553 | 0.97 (0.39 to 1.77) | 1.10 (0.60 to 1.72) | 0.13 | 4399 | 0.58 | 0.59 | 0.61 |
| Maintained benefit of CC | 9338 (101 to 41 379) | 9858 (114 to 46 215) | 520 | 0.97 (0.39 to 1.77) | 1.12 (0.62 to 1.73) | 0.15 | 3468 | 0.60 | 0.61 | 0.62 |
| Growing benefit of CC—25%/cycle | 9338 (101 to 41 379) | 9788 (99 to 49 796) | 450 | 0.97 (0.39 to 1.77) | 1.19 (0.67 to 1.65) | 0.21 | 2103 | 0.63 | 0.65 | 0.66 |
| No deaths during follow-up | 9795 (104 to 43 576) | 10 278 (127 to 44 497) | 483 | 1.02 (0.40 to 1.87) | 1.04 (0.42 to 1.89) | 0.02 | 22 843 | 0.51 | 0.52 | 0.52 |
| Discount rate (costs and QALYs): 0% | 9391 (101 to 41 622) | 10 066 (125 to 43 368) | 675 | 0.98 (0.39 to 1.78) | 1.02 (0.41 to 1.84) | 0.04 | 16 098 | 0.53 | 0.54 | 0.56 |
| Discount rate (costs and QALYs): 5% | 9317 (101 to 41 278) | 9990 (124 to 43 008) | 674 | 0.97 (0.38 to 1.77) | 1.01 (0.41 to 1.82) | 0.04 | 16 133 | 0.53 | 0.54 | 0.56 |
Mean and net values presented in table have been rounded for clarity—non-rounded values were used to calculate the incremental cost-effectiveness ratios (ICERs).
CC, collaborative care; QALY, quality-adjusted life year; WTPT, willingness to pay threshold.