Table 3

Characteristics of survivors and non-survivors of severe obstetric sepsis following critical care admission

Severe sepsis survivorsSevere sepsis deathsUnadjusted OR (95% CI)Adjusted OR (95% CI)
n=610n=29
Recently pregnant387 (63.4)22 (75.9)1.8 (0.76 to 4.3)1.1 (0.42 to 3.0)
Maternal age, years
 <25234 (38.4)5 (17.2)1*1*
 25–34254 (41.7)15 (51.7)2.8 (0.99 to 7.7)2.2 (0.71 to 7.0)
 ≥35121 (19.9)9 (31.0)3.5 (1.1 to 10.6)3.3 (0.94 to 11.2)
Non-white ethnicity147 (24.1)7 (24.1)0.98 (0.39 to 2.5)0.59 (0.21 to 1.6)
Deprivation (IMD quintiles 4 and 5)354 (58.1)17 (58.6)1.02 (0.48 to 2.2)2.6 (1.03 to 6.7)
BMI, kg/m­2
 Unknown317 (52.1)13 (44.8)0.78 (0.17 to 3.7)1.2 (0.15 to 9.1)
 <25126 (20.7)3 (10.3)1*1*
 ≥25<3090 (14.8)7 (24.1)3.3 (0.8 to 13.3)5.2 (1.4 to 18.9)
 ≥3076 (12.5)6 (20.7)3.5 (0.9 to 14.6)6.3 (1.5 to 27.0)
History of immunosuppression13 (2.1)2 (6.9)3.3 (0.73 to 15.7)
Weeks gestation
 Antenatal
  ≥3716 (7.0)0 (0.0)
  25–36104 (47.5)3 (42.9)1*
  <2599 (45.2)4 (57.1)1.4 (0.31 to 6.4)
 Postnatal
  ≥37202 (54.9)14 (66.7)1*
  25–36114 (31.0)3 (14.3)0.38 (0.11 to 1.3)
  <2552 (14.1)4 (19.1)1.1 (0.35 to 3.5)
Recently pregnant women only
Parity
 0183 (48.9)9 (42.9)1*
 188 (23.5)7 (33.3)1.6 (0.58 to 4.5)
 ≥2103 (27.5)5 (23.8)1.0 (0.32 to 3.0)
Assisted conception24 (8.7)0 (0.0)
Mode of delivery
 Spontaneous vaginal89 (23.6)8 (36.4)1*
 Assisted vaginal28 (7.4)0 (0.0)
 Caesarean section227 (60.2)12 (54.6)0.59 (0.23 to 1.5)
 Termination23 (6.1)2 (9.1)0.97 (0.19 to 4.9)
 Ectopic10 (2.7)0 (0.0)
All multiple births24 (7.0)3 (15.0)2.3 (0.64 to 8.6)
Stillbirth(s)42 (21.9)4 (33.3)1.8 (0.5 to 6.2)
Hysterectomy16 (4.6)3 (15.0)3.6 (0.96 to 13.7)
<24 hours since delivery104 (27.6)8 (36.4)1.5 (0.61 to 3.7)
Source of infection†
 Pneumonia (chest infection)216 (35.4)12 (41.4)1.3 (0.60 to 2.7)
 Intrauterine infection69 (11.3)2 (6.9)0.58 (0.13 to 2.5)
 Pelvic infection47 (7.7)0 (0.0)
 UTI/pyelonephritis43 (7.1)0 (0.0)
 Septicaemia‡17 (2.8)2 (6.9)2.6 (0.57-11.7)
Number of organ system dysfunctions
 1221 (36.2)2 (6.9)1*
 2224 (36.7)8 (27.6)3.9 (0.83 to 18.7)
 ≥3165 (27.1)19 (65.5)12.7 (2.9 to 55.1)
Organ system dysfunction§
 Cardiovascular444 (72.8)24 (82.8)1.8 (0.68 to 4.8)
 Respiratory349 (57.2)26 (89.7)6.5 (1.9 to 21.6)8.1 (1.8 to 36.0)
 Metabolic acidosis322 (52.8)18 (62.1)1.5 (0.68 to 3.1)
 Renal39 (6.4)8 (27.6)5.6 (2.3 to 13.4)2.9 (0.94 to 9.3)
 Haematological52 (8.5)11 (37.9)6.5 (2.9 to 14.6)5.7 (2.0 to 16.0)
  • Bold typeface indicates statistically significant results. Figures are numbers (%) of women.‘–’ indicates OR estimate not possible due to zero incidence in either the case or control group.

  • *Reference group.

  • †Reasons for admission with a >5% frequency.

  • ‡Admitted with or onset during critical care admission.

  • §Organ system dysfunctions not mutually exclusive.

  • BMI, body mass index; IMD, Index of Multiple Deprivation; UTI, urinary tract infection.